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Titolo:
ASSESSMENT OF CORONARY RESERVE IN MAN - COMPARISON BETWEEN POSITRON EMISSION TOMOGRAPHY WITH OXYGEN-15-LABELED WATER AND INTRACORONARY DOPPLER TECHNIQUE
Autore:
MERLET P; MAZOYER B; HITTINGER L; VALETTE H; SAAL JP; BENDRIEM B; CROZATIER B; CASTAIGNE A; SYROTA A; RANDE JLD;
Indirizzi:
CEA,SERV HOSP FREDERIC JOLIOT,4 PL MARECHAL LECLERC F-91401 ORSAY FRANCE CHU HENRI MONDOR,SERV CARDIOL F-94010 CRETEIL FRANCE INSERM,U2 CRETEIL FRANCE
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 11, volume: 34, anno: 1993,
pagine: 1899 - 1904
SICI:
0161-5505(1993)34:11<1899:AOCRIM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; NONINVASIVE QUANTIFICATION; INPUT FUNCTION; (H2O)-O-15; PERFUSION; VASODILATATION; QUANTITATION; CIRCULATION; STENOSES; TTV03;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P. Merlet et al., "ASSESSMENT OF CORONARY RESERVE IN MAN - COMPARISON BETWEEN POSITRON EMISSION TOMOGRAPHY WITH OXYGEN-15-LABELED WATER AND INTRACORONARY DOPPLER TECHNIQUE", The Journal of nuclear medicine, 34(11), 1993, pp. 1899-1904

Abstract

This study compared positron emission tomography (PET) using oxygen-15-labeled water for measurement of coronary reserve with intracoronaryDoppler in patients with left anterior descending artery stenosis andpatients with no coronary lesion and a coronary reserve 3 as assessedby the invasive technique To determine whether PET measurement of coronary reserve is altered by partial volume effect, patients with left ventricular dysfunction due to idiopathic cardiomyopathy were studied with both techniques. Direct ultrasonic measurement of coronary reserve was performed the day prior to the PET study: a Doppler catheter wasplaced in the proximal left anterior descending artery; mean velocitywas recorded at baseline and after dipyridamole administration. Usinga time-of-flight PET system, patients underwent: (1) an intravenous bolus of oxygen-15-labeled water at baseline and 4 to 6 min after intravenous infusion of dipyridamole using the same protocol as for Dopplerstudy and (2) a F-18-fluorodeoxyglucose (FDG) myocardial imaging. Oxygen-1 5 time-activity curves were recorded in myocardial regions of interest (ROIs) drawn on a static FDG image Using the left ventricular time-activity curve as an input function, a standard model with a single-tissue compartment was fitted to the PET data; myocardial blood flowwas estimated as the blood-to-tissue transfer rate constant. Coronaryreserve measured by PET was well correlated with that measured by intracoronary Doppler (r = 0.98, p < 0.001 for global population). This PET method is an accurate and reliable tool to noninvasively measure coronary reserve in patients, even in those with left ventricular dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:21:56