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Titolo:
IMMUNE-RESPONSES IN INTERLEUKIN-2 DEFICIENT MICE
Autore:
KUNDIG TM; SCHORLE H; BACHMANN MF; HENGARTNER H; ZINKERNAGEL RM; HORAK I;
Indirizzi:
UNIV ZURICH,INST EXPTL CHIRURG,SCHMELZBERGSTR 12 CH-8006 ZURICH SWITZERLAND UNIV WURZBURG,INST VIROL & IMMUNOBIOL W-8700 WURZBURG GERMANY
Titolo Testata:
Science
fascicolo: 5136, volume: 262, anno: 1993,
pagine: 1059 - 1061
SICI:
0036-8075(1993)262:5136<1059:IIIDM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTIC CHORIOMENINGITIS VIRUS; VESICULAR STOMATITIS-VIRUS; T-CELL PROLIFERATION; NATURAL-KILLER CELLS; DIFFERENTIATION FACTOR; INFECTION; ACTIVATION; INVIVO; EXPRESSION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Kundig et al., "IMMUNE-RESPONSES IN INTERLEUKIN-2 DEFICIENT MICE", Science, 262(5136), 1993, pp. 1059-1061

Abstract

The role of costimulatory signals in T cell induction was evaluated in mice lacking the interleukin-2 (IL-2) gene. In vitro secondary antiviral T cell responses were absent unless IL-2 was added, confirming the crucial role of IL-2 in vitro. In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitisvirus were within normal ranges. B cell reactivity to vesicular stomatitis virus was not impaired. T helper cell responses were delayed butbiologically functional. Natural killer cell activity was markedly reduced but inducible. These normal in vivo immune responses in IL-2-deficient mice question the importance of IL-2 as defined by in vitro studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:53:51