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Titolo:
ZIDOVUDINE AND THYMUS HUMORAL FACTOR GAMMA-2 IN THE TREATMENT OF HIV-INFECTION - PRELIMINARY CLINICAL-EXPERIENCE
Autore:
MAGGIOLO F; TARAS A; PRAVETTONI MG; LEONE M; INGROSSO A; SUTER F;
Indirizzi:
GEN HOSP,DIV INFECT DIS,PIAZZALE SOLARO 3 I-2152 BUSTO ARSIZIO ITALY PHARMACIA,CLIN DEPT,RES & DEV MILAN ITALY
Titolo Testata:
Infection
fascicolo: 1, volume: 25, anno: 1997,
pagine: 35 - 38
SICI:
0300-8126(1997)25:1<35:ZATHFG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTHYMOSIN-ALPHA; HEPATITIS-B; THYMOPENTIN; INTERLEUKIN-2; EXPRESSION; THF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
F. Maggiolo et al., "ZIDOVUDINE AND THYMUS HUMORAL FACTOR GAMMA-2 IN THE TREATMENT OF HIV-INFECTION - PRELIMINARY CLINICAL-EXPERIENCE", Infection, 25(1), 1997, pp. 35-38

Abstract

A case-control, prospective, open-label, clinical trial to evaluate efficacy and Safety of a combined zidovudine/Thymus Humoral Factor Gamma-2 (THF) therapy in HIV-infected subjects was conducted in 13 patients. Twenty-six patients were included as controls receiving only zidovudine. The two groups of patients were matched according to sex, age, CDC stage of HIV infection, number of CD4+ T cells and type of previousopportunistic infections (if any) and all patients and controls were naive for antiretroviral therapy at the moment they entered the trial. The observation period was protracted up to 47 months (mean 28+/-13 months). No significant difference,vas observed between the two groups as far as surrogate markers of HIV disease progression are concerned, However, patients receiving zidovudine and THF showed a lower number of opportunistic complications, Only one patient in this group progressed to manifest AIDS while 9 of 18 controls presented disease progression, Four patients died in the case group, all of them were CDC stage IV at admission, and 15 of 26 died in the control group (all CDC stage IV at admission, and four patients who presented disease progression during the study period). Survival time was increased in the case group. The exact immunological effect of thymus hormones in HIV infection has still to be elucidated, but a possible therapeutic role of these agents is foreseeable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:22:47