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Titolo:
ALTERATIONS IN THEOPHYLLINE METABOLISM DURING THE 1ST YEAR OF LIFE
Autore:
KRAUS DM; FISCHER JH; REITZ SJ; KECSKES SA; YEH TF; MCCULLOCH KM; TUNG EC; CWIK MJ;
Indirizzi:
UNIV ILLINOIS,COLL PHARM,DEPT PHARM PRACTICE MC886,833 S WOOD ST,ROOM276 CHICAGO IL 60612 UNIV ILLINOIS,COLL PHARM,DEPT PHARM PRACTICE MC886,833 S WOOD ST,ROOM276 CHICAGO IL 60612 UNIV ILLINOIS,DEPT PEDIAT CHICAGO IL 60680 COOK CTY HOSP CHICAGO IL 60612
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 4, volume: 54, anno: 1993,
pagine: 351 - 359
SICI:
0009-9236(1993)54:4<351:AITMDT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATURATIONAL CHANGES; PREMATURE-INFANTS; PRETERM INFANTS; GESTATIONAL-AGE; CAFFEINE; APNEA; PHARMACOKINETICS; DISPOSITION; NEWBORN; AMINOPHYLLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Kraus et al., "ALTERATIONS IN THEOPHYLLINE METABOLISM DURING THE 1ST YEAR OF LIFE", Clinical pharmacology and therapeutics, 54(4), 1993, pp. 351-359

Abstract

Maturational changes in theophylline disposition were evaluated in 52infants (gestational age, 24 to 40 weeks; postnatal age, 2 to 69 weeks) receiving maintenance theophylline therapy. Theophylline and metabolites were measured in serum and urine at steady state, and the influence of clinical parameters on the maturational changes was analyzed bymultiple stepwise linear regression. Theophylline clearance and urinemetabolite pattern reached adult values at 55 weeks' postconceptionalage. Serum caffeine concentrations greater than 1 mug/ml occurred in infants up to 50 weeks' postconceptional age. Disappearance of serum caffeine concentrations and maturation of theophylline clearance were primarily related (p < 0.001) to development of the demethylation pathway to 3-methylxanthine. Postconceptional age was the major factor (p <0.001) explaining the interpatient variability in theophylline clearance (r2 = 0.57), serum caffeine to theophylline ratio (r2 = 0.46), andurinary excretion of theophylline (r2 = 0.51), caffeine (r2 = 0.49), 1,3-methyluric acid (r2 = 0.32), 1-methyluric acid (r2 = 0.53), and 3-methylxanthine (r2 = 0.58). Our findings indicate that postconceptional age rather than postnatal age should be used as a maturational marker during theophylline therapy in infancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 10:34:06