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Titolo:
TIME-DEPENDENT PHRENIC-NERVE RESPONSES TO CAROTID AFFERENT ACTIVATION- INTACT VS DECEREBELLATE RATS
Autore:
HAYASHI F; COLES SK; BACH KB; MITCHELL GS; MCCRIMMON DR;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL,303 E CHICAGO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT PHYSIOL,303 E CHICAGO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT ANESTHESIA CHICAGO IL 60611 UNIV WISCONSIN,DEPT COMPARAT BIOSCI MADISON WI 53706
Titolo Testata:
The American journal of physiology
fascicolo: 4, volume: 265, anno: 1993,
parte:, 2
pagine: 180000811 - 180000819
SICI:
0002-9513(1993)265:4<180000811:TPRTCA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOXIC VENTILATORY DEPRESSION; POSTERIOR CEREBELLAR CORTEX; RESPIRATORY RESPONSES; PROLONGED STIMULATION; ANESTHETIZED RATS; FASTIGIAL NUCLEUS; DECEREBRATE CAT; SINUS NERVE; NEURONS; MECHANISMS;
Keywords:
CAROTID SINUS NERVE; CEREBELLUM; LONG-TERM FACILITATION; PHRENIC NERVE; HYPOXIA; RAT; RESPIRATORY CONTROL; SHORT-TERM POTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F. Hayashi et al., "TIME-DEPENDENT PHRENIC-NERVE RESPONSES TO CAROTID AFFERENT ACTIVATION- INTACT VS DECEREBELLATE RATS", The American journal of physiology, 265(4), 1993, pp. 180000811-180000819

Abstract

The objectives were to determine 1) respiratory responses to carotid chemoreceptor inputs in anesthetized rats and 2) whether the cerebellar vermis plays a role in these responses. A carotid sinus nerve was stimulated (20 Hz) with five 2-min trains, each separated by approximately 3 min. During stimulation, respiratory frequency (f), peak amplitude of integrated phrenic nerve activity (integral Phr), and their product (f X integral Phr) immediately increased. As stimulation continued,integral Phr progressively increased to a plateau [short-term potentiation (STP)], but f and f X integral Phr decreased [short-term depression (STD)] to a value still above control. Upon stimulus termination, integral Phr progressively decreased but remained above control; f andf x f integral Phr transiently decreased below baseline. After the final stimulation, integral Phr remained above control for at least 30 min [long-term facilitation (LTF)]. Repeated 5-min episodes of isocapnic hypoxia also elicited STP, STD, and LTF. Vermalectomy lowered the CO2-apneic threshold and eliminated LTF. In conclusion, carotid chemoreceptor activation in rats elicits STP and LTF similar to that in cats; the vermis may play a role in LTF. A new response, STD, was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:37:56