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Titolo:
IS RAPID RISE IN VASCULAR CONDUCTANCE AT ONSET OF DYNAMIC EXERCISE DUE TO MUSCLE PUMP
Autore:
SHERIFF DD; ROWELL LB; SCHER AM;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHYSIOL & BIOPHYS,SJ-40 SEATTLE WA 98195
Titolo Testata:
The American journal of physiology
fascicolo: 4, volume: 265, anno: 1993,
parte:, 2
pagine: 80001227 - 80001234
SICI:
0002-9513(1993)265:4<80001227:IRRIVC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY RHYTHMIC EXERCISE; BLOOD-FLOW; SKELETAL-MUSCLE; CONSCIOUS DOGS; CARDIAC-OUTPUT; VASODILATION; PRESSURE; CONTRACTION; CIRCULATION; STIMULATION;
Keywords:
DOG; METABOLIC VASODILATION; MYOGENIC VASODILATION; AUTONOMIC NERVES; AUTONOMIC BLOCKADE; SYMPATHETIC NERVES; ATRIOVENTRICULAR BLOCK; CARDIAC OUTPUT; HINDLIMB BLOOD FLOW; MUSCLE BLOOD FLOW; ARTERIAL PRESSURE; CENTRAL VENOUS PRESSURE; TREADMILL EXERCISE; VASCULAR RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.D. Sheriff et al., "IS RAPID RISE IN VASCULAR CONDUCTANCE AT ONSET OF DYNAMIC EXERCISE DUE TO MUSCLE PUMP", The American journal of physiology, 265(4), 1993, pp. 80001227-80001234

Abstract

We tested the hypothesis that rapid increases in muscle blood flow and vascular conductance (C) at onset of dynamic exercise are caused by the muscle pump. We measured arterial (AP) and central venous pressure(CVP) in nine awake dogs, eight with atrioventricular block, pacemakers, and ascending aortic flow probes for control of cardiac output (CO) (2 also had terminal aortic flow probes). One dog had only an iliac artery probe. At exercise onset (0 and 10% grade, 4 mph) C and CVP rose to early plateaus, and AP reached a nadir, all in 2-5 s. At 20% grade and 4 mph, C increased continuously after its initial sudden rise. Timing and magnitude of initial change in conductance (DELTAC) were independent of CO, AP, work rate (change in grade at constant speed), or autonomic function (blocked by hexamethonium). Speed of initial DELTACand its independence from work rate and blood flow ruled out metabolic vasodilation as its cause; insensitivity to AP and autonomic blockade ruled out myogenic relaxation and sympathetic vasodilation as causesof sudden DELTAC. Sensitivity to contraction frequency (not work per se) implicates the muscle pump. When reflexes were blocked, a large secondary rise in C, presumably caused by metabolic vasodilation, began after 10 s of mild exercise. When reflexes were intact in mild exercise, C was lowered below its initial plateau by sympathetic vasoconstriction, which partially raised AP from its nadir toward its preexercise level. Our conclusion is that dynamic exercise has a large rapid effect on C that is not explained by known neural, metabolic, myogenic, or hydrostatic influences. We propose that muscle relaxation draws blood from arteries into veins at exercise onset, and this reduces AP. Venous blood is pumped centrally, raising CVP. The consequent increase in muscle blood flow, coupled with falling AP and rising CVP, markedly increases calculated C, which is actually a ''virtual conductance'' across a pump.

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Documento generato il 20/09/20 alle ore 22:48:22