Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ASSOCIATIONS OF POSTMENOPAUSAL ESTROGEN USE WITH CARDIOVASCULAR-DISEASE AND ITS RISK-FACTORS IN OLDER WOMEN
Autore:
MANOLIO TA; FURBERG CD; SHEMANSKI L; PSATY BM; OLEARY DH; TRACY RP; BUSH TL;
Indirizzi:
NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,FED BLDG,ROOM 301,7550 WISCONSIN AVE BETHESDA MD 20892 GEISINGER MED CLIN,DEPT RADIOL DANVILLE PA 00000 UNIV VERMONT,DEPT PATHOL BURLINGTON VT 05405 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL BALTIMORE MD 21218
Titolo Testata:
Circulation
fascicolo: 5, volume: 88, anno: 1993,
parte:, 1
pagine: 2163 - 2171
SICI:
0009-7322(1993)88:5<2163:AOPEUW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; FOLLOW-UP; CAROTID ATHEROSCLEROSIS; REPLACEMENT THERAPY; MORTALITY; HEALTH; COMMUNITY; ESTRADIOL; PLASMA;
Keywords:
CARDIOVASCULAR DISEASES; AGING; EPIDEMIOLOGY; RISK FACTORS; HORMONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Manolio et al., "ASSOCIATIONS OF POSTMENOPAUSAL ESTROGEN USE WITH CARDIOVASCULAR-DISEASE AND ITS RISK-FACTORS IN OLDER WOMEN", Circulation, 88(5), 1993, pp. 2163-2171

Abstract

Background. Postmenopausal estrogen replacement therapy has been associated with favorable levels of cardiovascular disease risk factors, but these associations and the relations between estrogen use and subclinical disease have not been examined in large samples of older women. Methods and Results. Present and past estrogen use was ascertained in2955 women greater-than-or-equal-to 65 years old in the Cardiovascular Health Study, a study of risk factors for coronary heart disease andstroke in the elderly. Present estrogen use was reported by 12% of these women and past use by an additional 26.5%. Estrogen use (past or present) was strongly associated with lower low-density lipoprotein cholesterol, fibrinogen, glucose, insulin, obesity, and age and higher high-density lipoprotein cholesterol and socioeconomic status (all P<.0001). Estrogen users also had lower levels of subclinical disease as measured by carotid intimal-medial thickness, carotid stenosis grade, ECG left ventricular mass, and Doppler mitral peak flow velocities (eachP<.02). Relations were similar in younger and older women (65 to 74 versus greater-than-or-equal-to 75 years) and smokers and nonsmokers and were unchanged after women with poor medication compliance were excluded. After adjustment for other factors, estrogen use was associated with decreased carotid wall thickness, although this association was of borderline significance after further adjustment for lipids. Conclusions. Postmenopausal estrogen use in this sample of older women was associated with favorable cardiovascular disease risk factor profiles and with lower measures of subclinical disease. These findings suggest that postmenopausal estrogen use may be associated with lower risk of cardiovascular disease in women well into the eighth decade of life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:54:54