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Titolo:
PRIOR GLUCOSE DEPRIVATION INCREASES THE FIRST-PHASE OF GLUCOSE-INDUCED INSULIN-RESPONSE - POSSIBLE INVOLVEMENT OF ENDOGENOUS ATP AND (OR) ADP
Autore:
CHAPAL J; BERTRAND G; HILLAIREBUYS D; GROSS R; LOUBATIERESMARIANI MM;
Indirizzi:
FAC MED MONTPELLIER,INST BIOL,PHARMACOL LAB,BLVD HENRI IV F-34060 MONTPELLIER FRANCE
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 8, volume: 71, anno: 1993,
pagine: 611 - 614
SICI:
0008-4212(1993)71:8<611:PGDITF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE PANCREATIC-ISLETS; PERFUSED RAT PANCREAS; ADENOSINE-TRIPHOSPHATE; P2-PURINOCEPTORS; NUCLEOTIDES; SECRETION; RELEASE; EFFLUX; HEART;
Keywords:
GLUCOSE; INSULIN SECRETION; ATP; ADP; PURINOCEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J. Chapal et al., "PRIOR GLUCOSE DEPRIVATION INCREASES THE FIRST-PHASE OF GLUCOSE-INDUCED INSULIN-RESPONSE - POSSIBLE INVOLVEMENT OF ENDOGENOUS ATP AND (OR) ADP", Canadian journal of physiology and pharmacology, 71(8), 1993, pp. 611-614

Abstract

A possible implication of endogenously released ATP and (or) ADP in insulin response to glucose stimulation was investigated in the isolated rat pancreas. The first phase of insulin response to the same glucose concentration (8.3 mM) was much higher in pancreas previously perfused in the absence of glucose than in pancreas previously perfused with4.2 mM glucose. A P-2 purinoceptor antagonist, 2,2'-pyridylisatogen tosylate, strongly reduced the higher first phase resulting from glucose deprivation; similarly, it reduced exogenous ATP-potentiated insulinresponse to a glucose increase from 4.2 to 8.3 mM. In contrast, 2,2'-pyridylisatogen tosylate did not modify the first phase of insulin response to 8.3 or 12.5 mM glucose in pancreas previously perfused with 4.2 mM glucose. Our results suggest that endogenous ATP and (or) ADP released in pancreatic islets in the absence of glucose could activate P-2 purinoceptors and increase the magnitude of the first phase of insulin response to a glucose stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:52:21