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Titolo:
DISSOCIATION OF BENZODIAZEPINE-INDUCED AMNESIA FROM SEDATION BY FLUMAZENIL PRETREATMENT
Autore:
HOMMER D; WEINGARTNER H; BREIER A;
Indirizzi:
NIAAA,CLIN SCI LAB,BLDG 10,ROOM 3B19,9000 ROCKVILLE PIKE BETHESDA MD 20894 UNIV MARYLAND,SCH MED,DEPT PSYCHIAT,MARYLAND PSYCHIAT RES CTR BALTIMORE MD 21201
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 112, anno: 1993,
pagine: 455 - 460
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE MEMORY-SYSTEMS; DIAZEPAM; PSYCHOMOTOR; PERFORMANCE; ANTAGONIST; RO-15-1788; RECEPTORS; EXPLICIT; REVERSAL; BRAIN;
Keywords:
BENZODIAZEPINE; FLUMAZENIL; MEMORY; ATTENTION; SEDATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
D. Hommer et al., "DISSOCIATION OF BENZODIAZEPINE-INDUCED AMNESIA FROM SEDATION BY FLUMAZENIL PRETREATMENT", Psychopharmacology, 112(4), 1993, pp. 455-460

Abstract

AThe human amnestic syndrome associated with lesions of the hippocampus and amygdala is characterized by a selective impairment of recent (explicit, episodic) memory. Benzodiazepine (BZ) treated normal subjects demonstrate similar, marked impairments in episodic memory, but in addition, BZ also induces sedation and inattention. Thus, the amnestic effects of BZ may be secondary to drug-induced sedation. However, whensubjects were pretreated with the specific BZ receptor antagonist, flumazenil, the sedative and attentional effects of diazepam were blocked, but a marked impairment in episodic memory still occurred. This demonstrates that, using neuropharmacological, methods, it is possible toproduce a dissociation of memory impairment from inattention and sedation. Such distinct patterns of cognitive dysfunction may serve as models for clinical cognitive syndromes.

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Documento generato il 19/09/20 alle ore 06:44:16