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Titolo:
PROTECTIVE EFFECT OF CARRAGEENAN AGAINST MURINE CYTOMEGALOVIRUS-INFECTION IN MICE
Autore:
HAMASUNA R; EIZURU Y; SHISHIME Y; MINAMISHIMA Y;
Indirizzi:
MIYAZAKI MED COLL,DEPT MICROBIOL MIYAZAKI 88916 JAPAN MIYAZAKI MED COLL,DEPT MICROBIOL MIYAZAKI 88916 JAPAN
Titolo Testata:
Antiviral chemistry & chemotherapy
fascicolo: 6, volume: 4, anno: 1993,
pagine: 353 - 360
SICI:
0956-3202(1993)4:6<353:PEOCAM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL RESPONSE MODIFIERS; KILLER NK CELLS; VIRUS; MECHANISM; INVIVO; CYCLOPHOSPHAMIDE; POLYSACCHARIDES; RESISTANCE; RECOVERY; PATHWAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
R. Hamasuna et al., "PROTECTIVE EFFECT OF CARRAGEENAN AGAINST MURINE CYTOMEGALOVIRUS-INFECTION IN MICE", Antiviral chemistry & chemotherapy, 4(6), 1993, pp. 353-360

Abstract

The protective effect of iota-carrageenan (CAR) was evaluated againstmurine cytomegalovirus (MCMV) infection in mice. Female ICR mice werechallenged intraperitoneally (i.p.) with 3 LD50 of salivary gland-passaged MCMV. More than 0.5 mg of CAR showed a protective effect on miceonly when CAR was administered i.p. and then MCMV was inoculated i.p. The protective effect of CAR was evidenced by an increase in plaque-forming unit per LD50 and a decrease in the titre of infectious virusesin the target organs. Neither a virucidal nor a virustatic effect on MCMV was evidenced for CAR. The protective effect of CAR seemed to be host-mediated. Pretreatment of mice with CAR augmented natural killer (NK) activity of the spleen cells without elevating the serum interferon level. However, administration of anti-asialo GM1 antibody did not nullify the inhibitory effect of CAR on virus replication in the target organs. MCMV infection induced leukopenia including neutropenia and lymphopenia in saline-treated mice. Pre-treatment with CAR protected mice from those signs, except for slight lymphopenia. Administration ofcyclophosphamide induced severe leukopenia including neutropenia and lymphopenia even in CAR-treated mice. Under such conditions, the protective effect of CAR against MCMV infection was abrogated by cyclophosphamide. Thus, the protective effect of CAR seems to be non-NK-mediated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:43:31