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Titolo:
CLASSIFICATION OF DRUGS BASED ON VISUALLY EVOKED-RESPONSES IN RATS
Autore:
SARKADI A; AMBRUS A; SZPORNY L;
Indirizzi:
G RICHTER LTD,CHEM WORKS,POB 27 H-1475 BUDAPEST 10 HUNGARY EURO PROFIL LTD BUDAPEST HUNGARY
Titolo Testata:
Neuropsychobiology
fascicolo: 3, volume: 28, anno: 1993,
pagine: 160 - 176
SICI:
0302-282X(1993)28:3<160:CODBOV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; LATERAL GENICULATE-BODY; PETIT-MAL EPILEPSY; AFTER-DISCHARGES; EEG ANALYSIS; STEREO-EEG; MODEL;
Keywords:
PHOTICALLY EVOKED AFTERDISCHARGE; TIME DOMAIN DESCRIPTORS; ANTIPSYCHOTICS; ANXIOLYTICS; VIGILANCE ENHANCER; ANTIDEPRESSANTS; DRUG CLASSIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Sarkadi et al., "CLASSIFICATION OF DRUGS BASED ON VISUALLY EVOKED-RESPONSES IN RATS", Neuropsychobiology, 28(3), 1993, pp. 160-176

Abstract

Quantified parameters of photically evoked afterdischarge and EEG background activity of visual cortex of freely moving rats were used as variables to obtain a t profile for each drug dosage. Behavioural scores were also used. The determination of the dose/time-effect profile ofa compound was based on normalization of data and on calculation of the first two factor values in comparison with pooled data of representatives of neuroleptic, anxiolytic, convulsant, petit mal anticonvulsant, antidepressant and psychostimulant drug classes. The compounds wereinvestigated in different dosages and/or routes of administration. The model and procedure are validated for antipsychotic, anxiolytic and vigilance enhancer effect, and comprise the predictability of proconvulsive and petit mal anticonvulsive effects.

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Documento generato il 24/09/20 alle ore 03:31:01