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Titolo:
POSSIBLE INVOLVEMENT OF DOPAMINE IN THE LONG-TERM SEROTONIN DEPLETIONBY P-CHLOROAMPHETAMINE AND BETA,BETA-DIFLUORO-P-CHLOROAMPHETAMINE IN RATS
Autore:
HENDERSON MG; PERRY KW; FULLER RW;
Indirizzi:
ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR INDIANAPOLIS IN 46285 ELI LILLY & CO,LILLY RES LAB,LILLY CORP CTR INDIANAPOLIS IN 46285
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 267, anno: 1993,
pagine: 417 - 424
SICI:
0022-3565(1993)267:1<417:PIODIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
IPRINDOLE-TREATED RATS; BRAIN-SEROTONIN; 5-HYDROXYTRYPTAMINE; AMPHETAMINE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; 4-CHLOROAMPHETAMINE; NEUROTOXICITY; NEURONS; METHAMPHETAMINE; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Henderson et al., "POSSIBLE INVOLVEMENT OF DOPAMINE IN THE LONG-TERM SEROTONIN DEPLETIONBY P-CHLOROAMPHETAMINE AND BETA,BETA-DIFLUORO-P-CHLOROAMPHETAMINE IN RATS", The Journal of pharmacology and experimental therapeutics, 267(1), 1993, pp. 417-424

Abstract

The role of dopamine in the long-term depletion of serotonin in rat brain by p-chloroamphetamine (PCA) and related compounds was investigated by comparing effects of beta,beta-difluoro-p-chloroamphetamine (beta,beta-difluoro-PCA) and 4-methyl-alpha-ethyl-meta-tyramine (H75/12), reported to cause only short-term serotonin depletion, with those of PCA. A single dose of beta,beta-difluoro-PCA had no long-term effects on serotonin in whole rat brain, even after pretreatment with proadifenwhich decreased the rate at which beta,beta-difluoro-PCA disappeared from brain. The possibility that proadifen might antagonize serotonin depletion was ruled out; proadifen did not prevent long-term serotonindepletion by PCA. Long-term depletion of brain serotonin was found after repeated injections of beta,beta-difluoro-PCA (five injections 4 hr apart) and was prevented by fluoxetine pretreatment. 3,3-Difluoro-PCA given after the monoamine oxidase inhibitor pargyline or after carbidopa/L-dopa also caused long-term serotonin depletion, although H75/12did not. At early times after single doses producing the same initialdepletion of serotonin, PCA caused a large increase in dopamine and alarge decrease in the metabolite 3,4-dihydroxyphenylacetic acid in whole brain, thereby increasing the ratio dopamine/3,4-dihydroxyphenylacetic, and the other two drugs caused smaller effects. Extracellular dopamine was increased markedly by PCA, less by beta,beta-difluoro-PCA, and not at all by H75/12. These results suggest an association betweendopamine release and long-term depletion of serotonin and add to evidence that dopamine release by PCA may be essential to its neurotoxic actions on brain serotonin neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:34:15