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Titolo:
EXPRESSION OF THE C-ERBB-2-ENCODED ONCOPROTEIN AND PROGESTERONE-RECEPTOR IN HUMAN MENINGIOMAS
Autore:
SCHLEGEL J; ULLRICH B; STUMM G; GASS P; HARWERTH IM; HYNES NE; KIESSLING M;
Indirizzi:
INST PATHOL,FRANZ JOSEF STR ALLEE D-93042 REGENSBURG GERMANY UNIV HEIDELBERG,INST NEUROPATHOL D-69120 HEIDELBERG GERMANY FRIEDRICH MIESCHER INST CH-4002 BASEL SWITZERLAND
Titolo Testata:
Acta Neuropathologica
fascicolo: 5, volume: 86, anno: 1993,
pagine: 473 - 479
SICI:
0001-6322(1993)86:5<473:EOTCOA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; SEX STEROID-RECEPTORS; HER-2/NEU PROTOONCOGENE; PROTEIN EXPRESSION; BREAST-CANCER; CELL-LINES; AMPLIFICATION; CARCINOMA; FRAGMENTS; NEOPLASMS;
Keywords:
MENINGIOMA; ARACHNOID CAP CELL; C-ERBB-2; PROGESTERONE RECEPTOR; ONCOGENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J. Schlegel et al., "EXPRESSION OF THE C-ERBB-2-ENCODED ONCOPROTEIN AND PROGESTERONE-RECEPTOR IN HUMAN MENINGIOMAS", Acta Neuropathologica, 86(5), 1993, pp. 473-479

Abstract

The present study investigated the expression of c-erbB-2 in 59 meningiomas, including different histological subtypes and anaplastic variants, by immunocytochemistry and molecular biological techniques. Immunohistochemistry using the monoclonal antibody FWP-51 directed against c-erbB-2-encoded oncoprotein gp185 demonstrated variable degrees of immunoreactivity in all meningiomas. The intensity of immunostaining correlated with the degree of expression as assessed by Western analysis in 28 meningiomas using polyclonal antiserum 21N. There was no correlation between the degree of expression and histological variants. Immunoreactivity of all meningiomas was distinctly less intense, however, than that of the human breast cancer cell line SK-BR-3, and slightly lower than that of brain metastases of breast and ovarian carcinomas that served as positive controls for both methods. By Southern analysis all meningiomas showed a single copy of the c-erbB-2 gene. Non-neoplastic arachnoid cap cells also exhibited c-erbB-2 expression and the degree of immunoreactivity was comparable with the majority of meningiomas. These data argue against an overexpression of c-erbB-2 in meningiomas, but rather indicate a cell-type-specific constitutive expression ofthe c-erbB-2 gene product in meningiomas and their putative progenitor cells. Since a subgroup of meningiomas is known to express progesterone receptors (PR), gp185 immunoreactivity was compared to the hormonereceptor status using monoclonal antibody KD68. Fifty-six percent meningiomas showed PR immunoreactivity, but there was no statistically significant correlation with the degree of gp185 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 06:56:56