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Titolo:
DO HUMAN PEYER PATCHES CONTRIBUTE TO THE INTESTINAL INTRAEPITHELIAL-GAMMA-DELTA T-CELL POPULATION
Autore:
FARSTAD IN; HALSTENSEN TS; FAUSA O; BRANDTZAEG P;
Indirizzi:
NATL HOSP NORWAY,INST PATHOL,IMMUNOHISTOCHEM & IMMUNOPATHOL LAB N-0027 OSLO NORWAY UNIV OSLO,NATL HOSP,MED DEPT A,GASTROENTEROL SECT OSLO 3 NORWAY
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 5, volume: 38, anno: 1993,
pagine: 451 - 458
SICI:
0300-9475(1993)38:5<451:DHPPCT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD8 ACCESSORY MOLECULE; V-DELTA-1 GENE SEGMENT; LYMPHOCYTES BEARING; CELIAC-DISEASE; GUT EPITHELIUM; ALPHA-BETA; RECEPTOR; EXPRESSION; TISSUE; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
I.N. Farstad et al., "DO HUMAN PEYER PATCHES CONTRIBUTE TO THE INTESTINAL INTRAEPITHELIAL-GAMMA-DELTA T-CELL POPULATION", Scandinavian journal of immunology, 38(5), 1993, pp. 451-458

Abstract

T-cell receptor gamma/delta+ (TCRgamma/delta+) lymphocytes in human Peyer's patches (PP) adjoining ileal mucosa were studied by monoclonal antibodies with paired immunofluorescence staining in situ and by flow-cytometric phenotyping of isolated cells. The proportion of gamma/delta+ T cells in the follicle-associated epithelium outside the M-cell areas (median 4.1%, range 2.2-30.1%) was similar to that in mucosal villous epithelium (median 4.4%, range 0.5-30.5%). Most intraepithelial gamma/delta cells (approximately 90%) expressed CD45R0 but only a few expressed CD8 (< 10%) and none L-Selectin; a dominating subset (median 46%) employed the Vdelta1/Jdelta1 gene product (range 22-100%). The M-cell areas lacked gamma/delta cells but contained clustered CD20+ and CD3+ lymphocytes. The subepithelial PP dome area and interfollicular (T-cell) zones, as well as the mucosal lamina propria, contained very few gamma/delta cells (median 1.7%, range 0.4-8.9%) which were dominated (88-100%) by the Vdelta2-encoded subset. Those in the dome area and lamina propria were often (approximately 75%) CD45R0+ (range 44-90%) while very few (approximately 2%) expressed L-selectin (range 0-15%). By contrast, CD45R0 expression on gamma/delta cells in the PP T-cell zones was relatively low ( approximately 46%) and that of L-selectin relatively high (approximately 43%). In conclusion, TcR gamma/delta+ cells are quite rare in human PP and belong mainly to the Vdelta2-encoded subset, thus being different from most intraepithelial gamma/delta cells that probably have another origin. The L-selectin+ fraction of PP gamma/delta cells presumably represent newly recruited 'naive' T lymphocytes while CD45R0+ gamma/delta cells both in PP and lamina propria are probably antigen-primed.

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Documento generato il 20/09/20 alle ore 04:15:47