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Titolo:
SEROTONERGIC INNERVATION OF THE HIPPOCAMPUS AND NUCLEUS-ACCUMBENS-SEPTI AND THE ANXIOLYTIC-LIKE ACTION OF THE 5-HT(3) RECEPTOR ANTAGONISTS
Autore:
STEFANSKI R; PALEJKO W; BIDZINSKI A; KOSTOWSKI W; PLAZNIK A;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND MED ACAD,DEPT EXPTL & CLIN PHARMACOL PL-00927 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT BIOCHEM PL-02957 WARSAW POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 10, volume: 32, anno: 1993,
pagine: 987 - 993
SICI:
0028-3908(1993)32:10<987:SIOTHA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; ANXIETY; SUBTYPES; GR38032F; BEHAVIOR; DOPAMINE; AMYGDALA; INVIVO; SITES; DRUGS;
Keywords:
ANXIETY; 5-HT3 RECEPTOR ANTAGONISTS; HIPPOCAMPUS; NUCLEUS ACCUMBENS SEPTI; 5,7-DHT LESIONS; OPEN-FIELD TEST; VOGEL TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Stefanski et al., "SEROTONERGIC INNERVATION OF THE HIPPOCAMPUS AND NUCLEUS-ACCUMBENS-SEPTI AND THE ANXIOLYTIC-LIKE ACTION OF THE 5-HT(3) RECEPTOR ANTAGONISTS", Neuropharmacology, 32(10), 1993, pp. 987-993

Abstract

The roles of hippocampus (HP) and the nucleus accumbens septi (NAS) in the anxiolytic activity of two 5-HT3 receptor antagonists were studied in two animal models of anxiety, in rats. Injection of tropisetron (0.005 and 0.01 ug) or ondansetron (1.0 and 2.5 mug) into the hippocampus increased punished consumption of water in the Vogel conflict test. In the open field test neither 5-HT3 receptor antagonists had anxiolytic-like effects. Tropisetron (0.01 and 0.025 mug) injected into the NAS caused a marked increase in punished drinking, while ondansetron (0.01-15.0 mug) had no effect. In the open field test, tropisetron (0.001, 0.005 and 0.01 mug) and ondansetron (1.0 and 2.5 mug) given to theNAS increased the number of entries into the central part of the open-field, and the time spent in the central sector of the arena. Depletion of 5-HT significantly enhanced the anxiolytic-like effect of intra-NAS-injected tropisetron in the open field, at the dose of 0.005 mug, Moreover, 5,7-DHT lesions produced a tendency to increase motor activity in tropisetron-treated rats. Both hippocampal and accumbens 5-HT3 receptors seem to contribute to the anxiolytic-like effects of 5-HT3 antagonists in the Vogel test. It also appears that this effect of 5-HT3receptor antagonists is related to their action on postsynaptic 5-HT3receptors within the NAS, and depends on the functional state of the 5-HT innervation ascending from the raphe nuclei. Thus, the present data add more arguments for the more specific involvement of this limbicnucleus in emotional control.

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Documento generato il 07/07/20 alle ore 15:36:46