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Titolo:
SEROTONERGIC INNERVATION OF THE HIPPOCAMPUS AND NUCLEUS-ACCUMBENS-SEPTI AND THE ANXIOLYTIC-LIKE ACTION OF MIDAZOLAM AND 5-HT(1A) RECEPTOR AGONISTS
Autore:
STEFANSKI R; PALEJKO W; BIDZINSKI A; KOSTOWSKI W; PLAZNIK A;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND MED ACAD,DEPT EXPTL & CLIN PHARMACOL PL-00927 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT BIOCHEM PL-02957 WARSAW POLAND
Titolo Testata:
Neuropharmacology
fascicolo: 10, volume: 32, anno: 1993,
pagine: 977 - 985
SICI:
0028-3908(1993)32:10<977:SIOTHA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODELS; 5-HT1A RECEPTORS; ANXIETY; DOPAMINE; RAT; 5-HYDROXYTRYPTAMINE; 8-OH-DPAT; BUSPIRONE; DIAZEPAM; NEURONS;
Keywords:
ANXIETY; MIDAZOLAM; 5-HT1A AGONISTS; HIPPOCAMPUS; NUCLEUS ACCUMBENS SEPTI; 5,7-DHT LESIONS; OPEN-FIELD TEST; VOGEL TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R. Stefanski et al., "SEROTONERGIC INNERVATION OF THE HIPPOCAMPUS AND NUCLEUS-ACCUMBENS-SEPTI AND THE ANXIOLYTIC-LIKE ACTION OF MIDAZOLAM AND 5-HT(1A) RECEPTOR AGONISTS", Neuropharmacology, 32(10), 1993, pp. 977-985

Abstract

An involvement of serotonergic innervation of the hippocampus (HP) and the nucleus accumbens septi (NAS) in anxiolytic activity of benzodiazepine midazolam and 5-HT1A receptor agonists was studied in two different animal models of anxiety. Injection of midazolam (10.0 and 20.0 mug) or 8-OH-DPAT (0.5 and 1.0 mug) into the hippocampus increased punished consumption of water in the Vogel conflict test. Buspirone given at 0.1, 0.5 and 1.0 mug was ineffective in the Vogel test, while at 5.0 mug it enhanced shock-induced suppression of drinking. In the open-field test midazotam (0.01 and 0.1 mug), 8-OH-DPAT (0.1, 0.5 and 1.0 mug) and buspirone (2.5 and 5.0 mug) increased the number of entries into the central part of the open-field and the time spent in the centralsector. Depletion of 5-HT had no influence on the anxiolytic-like effect in the open-field test of intrahippocampally-administered 8-OH-DPAT (0.5 mug), but the drug tended to increase motor activity in lesioned animals. Midazolam and buspirone injected into the NAS did not have an anxiolytic effect in the Vogel test. A small increase in punished drinking was observed after 8-OH-DPAT (1.0 and 2.5 mug). Following intra-NAS injection, midazolam, 8-OH-DPAT and buspirone all failed to produce any marked anxiolytic-like effect in the open-field test. It appears that the hippocampus, rather than the NAS, is involved in mediatinganxiolytic-like effects of 5-HT1A receptor agonists. Hippocampal postsynaptic 5-HT1A receptors may account for the anti-emotional influenceof this group of drugs. The results indicate some similarities in thepsychotropic profile of 5-HT1A receptor agonists and midazolam.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:56:39