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Titolo:
PERFUSION WITH PICROLIV REVERSES BIOCHEMICAL-CHANGES INDUCED IN LIVERS OF RATS TOXICATED WITH GALACTOSAMINE OR THOACETAMIDE
Autore:
DWIVEDI Y; RASTOGI R; GARG NK; DHAWAN BN;
Indirizzi:
CENT DRUG RES INST,ICMR,CTR ADV PHARMACOL RES TRADIT REMEDIES LUCKNOW226001 UTTAR PRADESH INDIA CENT DRUG RES INST,ICMR,CTR ADV PHARMACOL RES TRADIT REMEDIES LUCKNOW226001 UTTAR PRADESH INDIA
Titolo Testata:
Planta medica
fascicolo: 5, volume: 59, anno: 1993,
pagine: 418 - 420
SICI:
0032-0943(1993)59:5<418:PWPRBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEPATIC DAMAGE; HEPATOPROTECTIVE ACTIVITY; PICRORHIZA-KURROA; SKELETAL-MUSCLE; MEMBRANE;
Keywords:
GALACTOSAMINE; THIOACETAMIDE; PICROLIV PERFUSION; HEPATOTOXICITY; HEPATIC ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y. Dwivedi et al., "PERFUSION WITH PICROLIV REVERSES BIOCHEMICAL-CHANGES INDUCED IN LIVERS OF RATS TOXICATED WITH GALACTOSAMINE OR THOACETAMIDE", Planta medica, 59(5), 1993, pp. 418-420

Abstract

Perfusion of liver of rats toxicated with galactosamine or thioacetamide with a 0.02% solution of picroliv (glycoside fraction of Picrorhiza kurroa) for 30 min (1 ml/min; 6 mg/rat), significantly reversed toxicant-induced changes in the activities of several enzymes. Galactosamine induced increases in the activities of alkaline phosphatase, gamma-glutamyl transpeptidase, acid ribonuclease, acid phosphatase, succinate dehydrogenase and decreases in the activities of Na+-K+-adenosine triphosphatase (ATPase) and glucose-6-phosphatase (reversed by 40-87%). Similarly, thioacetamide-induced inhibitions of the activities of Na+-K+-ATPase, Ca++-ATPase, Mg++-ATPase, succinate dehydrogenase and elevations in the activities of alkaline phosphatase, gamma-glutamyl transpeptidase, and acid ribonuclease were also significantly reversed. A significant reversal of the toxicants-induced decrease in [C-14]-leucineincorporation was also observed. These results indicate that picrolivcan also reverse D-galactosamine- or thioacetamide-induced hepatic damage in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:57:05