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Titolo: PERFUSION WITH PICROLIV REVERSES BIOCHEMICAL-CHANGES INDUCED IN LIVERS OF RATS TOXICATED WITH GALACTOSAMINE OR THOACETAMIDE
Autore: DWIVEDI Y; RASTOGI R; GARG NK; DHAWAN BN;
- Indirizzi:
- CENT DRUG RES INST,ICMR,CTR ADV PHARMACOL RES TRADIT REMEDIES LUCKNOW226001 UTTAR PRADESH INDIA CENT DRUG RES INST,ICMR,CTR ADV PHARMACOL RES TRADIT REMEDIES LUCKNOW226001 UTTAR PRADESH INDIA
- Titolo Testata:
- Planta medica
fascicolo: 5,
volume: 59,
anno: 1993,
pagine: 418 - 420
- SICI:
- 0032-0943(1993)59:5<418:PWPRBI>2.0.ZU;2-K
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- INDUCED HEPATIC DAMAGE; HEPATOPROTECTIVE ACTIVITY; PICRORHIZA-KURROA; SKELETAL-MUSCLE; MEMBRANE;
- Keywords:
- GALACTOSAMINE; THIOACETAMIDE; PICROLIV PERFUSION; HEPATOTOXICITY; HEPATIC ENZYMES;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 17
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- Y. Dwivedi et al., "PERFUSION WITH PICROLIV REVERSES BIOCHEMICAL-CHANGES INDUCED IN LIVERS OF RATS TOXICATED WITH GALACTOSAMINE OR THOACETAMIDE", Planta medica, 59(5), 1993, pp. 418-420
Abstract
Perfusion of liver of rats toxicated with galactosamine or thioacetamide with a 0.02% solution of picroliv (glycoside fraction of Picrorhiza kurroa) for 30 min (1 ml/min; 6 mg/rat), significantly reversed toxicant-induced changes in the activities of several enzymes. Galactosamine induced increases in the activities of alkaline phosphatase, gamma-glutamyl transpeptidase, acid ribonuclease, acid phosphatase, succinate dehydrogenase and decreases in the activities of Na+-K+-adenosine triphosphatase (ATPase) and glucose-6-phosphatase (reversed by 40-87%). Similarly, thioacetamide-induced inhibitions of the activities of Na+-K+-ATPase, Ca++-ATPase, Mg++-ATPase, succinate dehydrogenase and elevations in the activities of alkaline phosphatase, gamma-glutamyl transpeptidase, and acid ribonuclease were also significantly reversed. A significant reversal of the toxicants-induced decrease in [C-14]-leucineincorporation was also observed. These results indicate that picrolivcan also reverse D-galactosamine- or thioacetamide-induced hepatic damage in rats.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 11:52:02