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Titolo:
IMMUNOHISTOCHEMICAL LOCALIZATION OF PROTEOGLYCANS IN HUMAN PERIODONTIUM
Autore:
HAKKINEN L; OKSALA O; SALO T; RAHEMTULLA F; LARJAVA H;
Indirizzi:
UNIV TURKU,INST DENT,DEPT ORAL BIOL,LEMMINKAISENKATU 2 SF-20520 TURKU52 FINLAND UNIV TURKU,INST DENT,DEPT PERIODONTOL SF-20520 TURKU 52 FINLAND UNIV OULU,DEPT ORAL SURG SF-90100 OULU 10 FINLAND UNIV ALABAMA,SCH DENT,DEPT ORAL BIOL BIRMINGHAM AL 35294
Titolo Testata:
The Journal of histochemistry and cytochemistry
fascicolo: 11, volume: 41, anno: 1993,
pagine: 1689 - 1699
SICI:
0022-1554(1993)41:11<1689:ILOPIH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERMATAN SULFATE PROTEOGLYCAN; CHONDROITIN SULFATE; CONNECTIVE-TISSUE; HIGH ENDOTHELIUM; HUMAN-FIBROBLASTS; CELLS-INVITRO; HUMAN-SKIN; DECORIN; FIBRONECTIN; COLLAGEN;
Keywords:
PROTEOGLYCANS; HUMAN PERIODONTIUM; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
L. Hakkinen et al., "IMMUNOHISTOCHEMICAL LOCALIZATION OF PROTEOGLYCANS IN HUMAN PERIODONTIUM", The Journal of histochemistry and cytochemistry, 41(11), 1993, pp. 1689-1699

Abstract

Proteoglycans (PGs) are extracellular and cell surface-associated macromolecules that regulate cell adhesion, cell growth, matrix formation, and bind growth factors. In this work we studied the distribution ofcore proteins of four PGs (decorin, biglycan, a large molecular weight PG, and CD44) in human gingiva and periodontal ligament by immunohistochemical staining of frozen tissue sections with specific antibodies. Decorin, a major PG of this tissue, was localized on collagen fiber bundles in the gingival and periodontal connective tissues. Staining for decorin was most intense at the subepithelial region. Biglycan was a minor PG component of the human periodontium, showing some accumulation in connective tissue under the oral epithelium. At the immunohistochemical level, biglycan appeared to form fine filament-like structures on extracellular matrix fibers. Localization of large molecular weight PG differed from that of decorin and biglycan. It was concentrated in deep connective tissue areas of the gingiva and in the periodontal ligament, and was only weakly present at the subepithelial region. CD44 was mainly concentrated in cell-cell contact areas of basal and spinous layers of oral epithelium. In the connective tissue of gingiva andperiodontal ligament, CD44 was localized on fibroblast cell surfaces. Connective tissue area under the junctional epithelium contained relatively small amounts of PGs. The results indicate that different partsof human periodontium contain a typical variety of PGs, suggesting a specific function for each PG species in the location at which they accumulate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:25:59