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Titolo:
CIGUATERA ON KAUAI - INVESTIGATION OF FACTORS ASSOCIATED WITH SEVERITY OF ILLNESS
Autore:
KATZ AR; TERRELLPERICA S; SASAKI DM;
Indirizzi:
UNIV HAWAII,SCH PUBL HLTH,DEPT PUBL HLTH SCI,1960 E W RD HONOLULU HI 96822 HAWAII STATE DEPT HLTH,DIV COMMUN DIS,ZOONOSES SECT HONOLULU HI 96801 HAWAII STATE DEPT HLTH,KAUAI DIST HLTH OFF LIHUE HI 00000
Titolo Testata:
The American journal of tropical medicine and hygiene
fascicolo: 4, volume: 49, anno: 1993,
pagine: 448 - 454
SICI:
0002-9637(1993)49:4<448:COK-IO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATES VIRGIN-ISLANDS; COMMON-SOURCE OUTBREAK; FISH-TISSUES; CIGUATOXIN; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A.R. Katz et al., "CIGUATERA ON KAUAI - INVESTIGATION OF FACTORS ASSOCIATED WITH SEVERITY OF ILLNESS", The American journal of tropical medicine and hygiene, 49(4), 1993, pp. 448-454

Abstract

Epidemiologic characterization of ciguatera fish poisoning has been limited by lack of laboratory confirmation, absence of prospective follow-up, and incomplete analysis of age-related factors. A 1985 outbreakon the island of Kauai in the state of Hawaii that involved 15 persons of various ages was investigated to determine factors associated with disease severity. The presence of ciguatoxin was detected in leftover portions of the implicated fish by enzyme immunoassay. All cases were medically and epidemiologically investigated and followed prospectively. Ten of the 15 cases demonstrated bradycardia; seven were hospitalized, including two requiring placement in intensive care. Bradycardiawas associated with increasing age and body weight (P < 0.01 and < 0.05, respectively) as well as the amount of toxic fish consumed (P < 0.0 1). Duration of illness ranged from two to 132 days. Increasing duration of illness was correlated with both increasing age and weight (r(s) = 0.64 and r(s) = 0.72, respectively, both P < 0.01) and was independent of amount and components of toxic fish consumed. The correlationbetween increasing age and weight with duration and severity of symptoms may be explained by prior subclinical toxin exposure and is consistent with the observation that repeated ciguatoxin exposures are associated with more severe illness. The association between amount of toxic fish consumed and bradycardia is consistent with an increased dose of ciguatoxin. The findings of this outbreak investigation support previously unconfirmed observations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 20:46:04