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Titolo:
THE RAT GASTRIC PHOSPHOLIPIDS - INCREASED IN ULCERATED MUCOSA AND DECREASED AFTER HEALING
Autore:
DUNJIC BS; SVENSSON I; AXELSON J; ADLERCREUTZ P; ARRAJAB A; BENGMARK S;
Indirizzi:
LUND UNIV,DEPT SURG S-22185 LUND SWEDEN LUND UNIV,DEPT BIOTECHNOL S-22185 LUND SWEDEN
Titolo Testata:
European surgical research
fascicolo: 6, volume: 25, anno: 1993,
pagine: 376 - 382
SICI:
0014-312X(1993)25:6<376:TRGP-I>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE HYDROPHOBICITY; BARRIER; PROSTAGLANDIN; INDOMETHACIN; STOMACH; ASPIRIN; DAMAGE;
Keywords:
LYSOPHOSPHATIDYLCHOLINE; SPHINGOMYELIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLETHANOLAMINE; FATTY ACIDS; RAT; GASTRIC MUCOSA; CHRONIC ULCER; INDOMETHACIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Dunjic et al., "THE RAT GASTRIC PHOSPHOLIPIDS - INCREASED IN ULCERATED MUCOSA AND DECREASED AFTER HEALING", European surgical research, 25(6), 1993, pp. 376-382

Abstract

The composition and content of the gastric phospholipids were followed during development and healing of indomethacin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during the first 24 h afterindomethacin was given. The total phospholipid content and the content of lysophosphatidylcholine and phosphatidylcholine were increased onthe 5th day, when chronic ulcers were established. After 4 weeks, when the ulcers were healed, the total phospholipid content, and content of phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol, respectively, were decreased, while the content of lysophosphatidylcholine was increased. In conclusion, the composition and content ofgastric phospholipids were altered in rats with ulcers as well as in rats with healed ulcers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:16:11