Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CONTRACTILITY OF THE TAIL ARTERY IN RATS TREATED WITH BEZAFIBRATE ANDFED ATHEROGENIC DIET
Autore:
TRZECIAK HI; OKOPIEN B; KOZLOWSKI A; CHOCILOWSKA D; BARA A;
Indirizzi:
L WARYNSKI SILESIAN MED ACAD,DEPT PHARMACOL,UL MEDYKOW 18 PL-40752 KATOWICE POLAND L WARYNSKI SILESIAN MED ACAD,DEPT HYG & EPIDEMIOL PL-40752 KATOWICE POLAND
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 22, anno: 1993,
pagine: 761 - 767
SICI:
0160-2446(1993)22:5<761:COTTAI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; HIGH-CHOLESTEROL DIET; ALPHA-ADRENOCEPTORS; HYPERCHOLESTEROLEMIC RABBITS; AORTA; VASOCONSTRICTOR; ATHEROSCLEROSIS; CELLS; NOREPINEPHRINE; MODULATION;
Keywords:
BEZAFIBRATE; ATHEROGENIC DIET; HYPERCHOLESTEROLEMIA; VASCULAR SMOOTH MUSCLE CONTRACTILITY; ALPHA-ADRENOCEPTOR; RAT TAIL ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
H.I. Trzeciak et al., "CONTRACTILITY OF THE TAIL ARTERY IN RATS TREATED WITH BEZAFIBRATE ANDFED ATHEROGENIC DIET", Journal of cardiovascular pharmacology, 22(5), 1993, pp. 761-767

Abstract

Bezafibrate, a potent hypolipidemic agent, was studied as potentiallypreventive in the atherosclerosis-associated vascular hyperresponsiveness to alpha-adrenoceptors agonists in rats. Contractile responses tonorepinephrine (NE) were determined in isolated tail arteries of ratsfed an atherogenic or a standard diet. Atherogenic diet was biochemically confirmed to induce hypercholesterolemia. Used for 1 month, atherogenic diet increased pressor responses to NE in physiologic salt solution (PSS) and Ca2+-free PSS. When bezafibrate (100 mg/kg orally, p.o.) was administered simultaneously with atherogenic diet for 1 month, the effect was inhibited, but bezafibrate administered from day 15 of our experiment had no effect on vasoconstrictor responses to NE. Bezafibrate prevented changes in contractile responses of rat tail artery inthe early stages of atherogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:02:30