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Titolo:
STUDIES OF MONOCLONAL-ANTIBODY BL2-10D1 AS A MARKER FOR THE DETECTIONOF THE UROTHELIAL ORIGIN OF TUMORS
Autore:
LONGIN A; BERGERDUTRIEUX N; FONTANIERE B; COCHRAN AJ; DEVONEC M; DOLBEAU D; GUILLAUD M; LAURENT JC;
Indirizzi:
CTR LEON BERARD,SERV CYTOL ANALYT,28 RUE LAENNEC F-69373 LYON 08 FRANCE CTR LEON BERARD,SERV CYTOL ANALYT,28 RUE LAENNEC F-69373 LYON 08 FRANCE HOP HOTEL DIEU LYON FRANCE CTR REG TRANSFUS SANGUINE MARSEILLE FRANCE HOP ANTIQUAILLE F-69321 LYON 1 FRANCE UNIV CALIF LOS ANGELES,DEPT PATHOL & LAB MED LOS ANGELES CA 90024
Titolo Testata:
Cancer
fascicolo: 9, volume: 72, anno: 1993,
pagine: 2651 - 2655
SICI:
0008-543X(1993)72:9<2651:SOMBAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSITIONAL CELL-CARCINOMA; PROSTATIC-SPECIFIC ANTIGEN; HUMAN BLADDER; URINARY-BLADDER; ADENOCARCINOMA; CANCER; BREAST; IMMUNOHISTOCHEMISTRY; HETEROGENEITY;
Keywords:
MONOCLONAL ANTIBODY; METASTASES; TRANSITIONAL CELL CARCINOMA; BLADDER CANCER; PROSTATIC CANCER; IMMUNOPEROXIDASE STAINING; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Longin et al., "STUDIES OF MONOCLONAL-ANTIBODY BL2-10D1 AS A MARKER FOR THE DETECTIONOF THE UROTHELIAL ORIGIN OF TUMORS", Cancer, 72(9), 1993, pp. 2651-2655

Abstract

Background. In previous studies, the authors demonstrated the value of the monoclonal antibody (MoAb) BL2-10D1 in identifying malignant transitional cells. In this study, the authors evaluate the possible diagnostic value of a murine MoAb, BL2-10D1, raised against human bladder cancer in the determination of the urothelial origin of metastases in a series of 29 patients with metastatic bladder or prostatic carcinoma. Methods. Using an immunoperoxidase method, BL2-10D1 and anti-prostate-specific antigen (anti-PSA) reactivity were studied, using histologic sections from 18 pelvic lymph nodes and 4 other anatomic sites invaded by transitional cell cancer, and from 7 pelvic lymph nodes containing prostatic cancer. Results. All lymph nodes containing metastases oftransitional cell carcinoma were positive with BL2-10D1, whereas all metastases of prostatic cancer were negative; the four instances of distant urothelial metastases were positive with BL2-10D1 MoAb. Conversely, anti-PSA reacted only with prostatic metastases. Conclusion. Thus,MoAb BL2-10D1 and anti-PSA complement each other in the separation ofcancers of prostatic and urothelial origin, and the BL2-10D1 MoAb haspotential usefulness in differentiating between urothelial carcinoma and prostate adenocarcinoma. In patients with bladder tumors of uncertain origin, BL2-10D1 may be helpful in confirming that a tumor is a transitional cell carcinoma.

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Documento generato il 18/09/20 alle ore 17:03:27