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Titolo:
PROTECTIVE EFFECTS OF GREEN TEA POLYPHENOLS ADMINISTERED BY ORAL INTUBATION AGAINST CHEMICAL CARCINOGEN-INDUCED FORESTOMACH AND PULMONARY NEOPLASIA IN A J MICE/
Autore:
KATIYAR SK; AGARWAL R; MUKHTAR H;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SKIN DIS RES CTR,DEPT DERMATOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SKIN DIS RES CTR,DEPT DERMATOL CLEVELAND OH 44106
Titolo Testata:
Cancer letters
fascicolo: 2-3, volume: 73, anno: 1993,
pagine: 167 - 172
SICI:
0304-3835(1993)73:2-3<167:PEOGTP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENCAR MOUSE SKIN; TUMOR INITIATION; INHIBITION; FRACTION; TUMORIGENESIS; -9-ALPHA,10-ALPHA-EPOXY-7,8,9,10-TETRAHYDROBENZO).; BENZO)A>PYRENE; MECHANISMS; PROMOTION; CANCER;
Keywords:
GREEN TEA POLYPHENOLS; CHEMOPREVENTION; FORESTOMACH AND LUNG TUMORIGENESIS; DIETHYLNITROSAMINE; BENZO(A)PYRENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Katiyar et al., "PROTECTIVE EFFECTS OF GREEN TEA POLYPHENOLS ADMINISTERED BY ORAL INTUBATION AGAINST CHEMICAL CARCINOGEN-INDUCED FORESTOMACH AND PULMONARY NEOPLASIA IN A J MICE/", Cancer letters, 73(2-3), 1993, pp. 167-172

Abstract

Our studies and others have shown the cancer chemopreventive effects of chronic administration of green tea in several animal tumor models. In this study, the administration of a polyphenolic fraction isolatedfrom green tea (GTP) by oral intubation at a dose of 5 mg in 0.2 ml water 30 min prior to challenge with carcinogen, afforded significant protection against both diethylnitrosamine (DEN)- and benzo(a)pyrene (BP)-induced forestomach and lung tumorigenesis in A/J mice. The protective effects were evident by a decrease in numbers of tumors/mouse in GTP-fed groups compared to non GTP-fed controls. In the forestomach tumorigenesis protocol, GTP afforded 71 and 66% protection against, respectively DEN- and BP-induced tumor multiplicity. In the case of lung tumorigenesis protocol, however, the protective effects of GTP were 41 and 39%, respectively. Histological examination of forestomach tumors showed significantly lesser number of squamous cell carcinoma formationin GTP-fed groups of mice compared to carcinogen alone-treated controls. When pulmonary tumors were examined histologically, no adenocarcinomas were observed in GTP-fed groups compared to 15% mice with adenocarcinomas in DEN and BP alone-treated controls. The results of this study suggest that limited doses of GTP administration by gavage 30 min prior to carcinogen challenge may afford protection against carcinogen-induced tumorigenesis in internal body organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:29:18