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Titolo:
MOUSE SKIN TUMOR-INITIATING ACTIVITY OF BENZ[J]ACEANTHRYLENE IN SENCAR MICE
Autore:
NESNOW S; GOLD A; SANGAIAH R; SLAGA TJ;
Indirizzi:
US EPA,HLTH EFFECTS RES LAB,CARCINOGENESIS & METAB BRANCH RES TRIANGLE PK NC 27711 UNIV N CAROLINA,DEPT ENVIRONM SCI & ENGN CHAPEL HILL NC 27514 UNIV TEXAS,CTR SYST CANC,DIV SCI PK RES SMITHVILLE TX 78957
Titolo Testata:
Cancer letters
fascicolo: 2-3, volume: 73, anno: 1993,
pagine: 73 - 76
SICI:
0304-3835(1993)73:2-3<73:MSTAOB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOPENTA-FUSED ISOMERS; CELLS; BENZ)L>ACEANTHRYLENE; BENZ)A>ANTHRACENE; METABOLITES; HYDROCARBON; BACTERIAL; RING;
Keywords:
BENZ[J]ACEANTHRYLENE; TUMOR INITIATION; SENCAR MICE; BENZO[A]PYRENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
S. Nesnow et al., "MOUSE SKIN TUMOR-INITIATING ACTIVITY OF BENZ[J]ACEANTHRYLENE IN SENCAR MICE", Cancer letters, 73(2-3), 1993, pp. 73-76

Abstract

Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T1/2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A/J mice. B[j]A was evaluated as a skin tumor initiator in female SENCARmice and was found to induce papilloma formation in the. range of 40-400 mug/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 mug/mouse. At this dose,100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremelypotent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:32:45