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Titolo:
GENETIC-STUDIES OF AFFECTIVE-DISORDERS - SHOULD WE BE STARTING WITH CHILDHOOD-ONSET PROBANDS
Autore:
TODD RD; NEUMAN R; GELLER B; FOX LW; HICKOK J;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,BOX 8134,4940 CHILDRENS PL ST LOUIS MO 63110
Titolo Testata:
Journal of the American Academy of Child and Adolescent Psychiatry
fascicolo: 6, volume: 32, anno: 1993,
pagine: 1164 - 1171
SICI:
0890-8567(1993)32:6<1164:GOA-SW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; FAMILY HISTORY METHOD; PSYCHIATRIC-DISORDERS; DSM-III; CHILDREN; RELATIVES; ILLNESS; LINKAGE; SCHIZOPHRENIA; DEPRESSION;
Keywords:
BIPOLAR AFFECTIVE DISORDER; MAJOR DEPRESSIVE DISORDER; SEGREGATION ANALYSIS; AGE-OF-ONSET; GENETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Todd et al., "GENETIC-STUDIES OF AFFECTIVE-DISORDERS - SHOULD WE BE STARTING WITH CHILDHOOD-ONSET PROBANDS", Journal of the American Academy of Child and Adolescent Psychiatry, 32(6), 1993, pp. 1164-1171

Abstract

Objective. The objective of this study is to test whether the presence of childhood onset affective disorder identifies families with increased incidence and severity of affective disorders. Method- Family history information was collected on the first and second degree relatives and first cousins age greater-than-or-equal-to 15 years of 22 children with bipolar affective disorder, 54 children with major depressive disorder, and 31 psychiatrically normal children. Results: Compared with the relatives of normal children, relatives identified through children with bipolar affective disorder or major depressive disorder had elevated rates of affective disorders and increased severity of affective disorders as judged by earlier age of onset and increased suicide attempts. Segregation analyses could reject purely environmental transmission of illness. Conclusion: Ascertaining families through childhood onset affective disorder probands identifies extended pedigrees withhigh incidence and severity of affective disorders. These families may be more appropriate for genetic analyses than are families of adult probands.

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Documento generato il 15/07/20 alle ore 07:16:54