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Titolo:
DECREASED PREFRONTAL DOPAMINE D1 RECEPTORS IN SCHIZOPHRENIA REVEALED BY PET
Autore:
OKUBO Y; SUHARA T; SUZUKI K; KOBAYASHI K; INOUE O; TERASAKI O; SOMEYA Y; SASSA T; SUDO Y; MATSUSHIMA E; IYO M; TATENO Y; TORU M;
Indirizzi:
TOKYO MED & DENT UNIV,SCH MED,DEPT NEUROPSYCHIAT,BUNKYO KU,1-5-45 YUSHIMA TOKYO 113 JAPAN NATL INST RADIOL SCI,DIV ADV TECHNOL MED IMAGING,INAGE KU CHIBA 263 JAPAN
Titolo Testata:
Nature
fascicolo: 6617, volume: 385, anno: 1997,
pagine: 634 - 636
SICI:
0028-0836(1997)385:6617<634:DPDDRI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; PREFRONTAL CORTEX; COGNITIVE ACTIVATION; WORKING-MEMORY; HUMAN-BRAIN; DYSFUNCTION; MODULATION; BINDING; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
Y. Okubo et al., "DECREASED PREFRONTAL DOPAMINE D1 RECEPTORS IN SCHIZOPHRENIA REVEALED BY PET", Nature, 385(6617), 1997, pp. 634-636

Abstract

Schizophrenia is believed to involve altered activation of dopamine receptors, and support for this hypothesis comes from the antipsychoticeffect of antagonists of the dopamine D2 receptor (D2R)(1). D2R is expressed most highly in the striatum, but most of the recent positron emission tomography (PET) studies have failed to show any change in D2Rdensities in the striatum of schizophrenics(2-5), raising the possibility that other receptors may also be involved. In particular, the dopamine D1 receptor (D1R), which is highly expressed in the prefrontal cortex(6), has been implicated in the control of working memory(7,8), and working memory dysfunction is a prominent feature of schizophrenia(9). We have therefore used PET to examine the distribution of D1R and D2R in brains of drug-naive or drug-free schizophrenic patients. Although no differences were observed in the striatum relative to control subjects, binding of radioligand to D1R was reduced in the prefrontal cortex of schizophrenics. This reduction was related to the severity ofthe negative symptoms (for instance, emotional withdrawal) and to poor performance in the Wisconsin Card Sorting Test(10). We propose that dysfunction of D1R signalling in the prefrontal cortex may contribute to the negative symptoms and cognitive deficits seen in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 23:00:51