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Titolo: ULCERATIVE COLITIS-LIKE DISEASE IN MICE WITH A DISRUPTED INTERLEUKIN-2 GENE
Autore: SADLACK B; MERZ H; SCHORLE H; SCHIMPL A; FELLER AC; HORAK I;
- Indirizzi:
- UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY MED UNIV LUBECK,INST PATHOL D-23562 LUBECK GERMANY
- Titolo Testata:
- Cell
fascicolo: 2,
volume: 75,
anno: 1993,
pagine: 253 - 261
- SICI:
- 0092-8674(1993)75:2<253:UCDIMW>2.0.ZU;2-K
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- INFLAMMATORY BOWEL-DISEASE; EMBRYONIC STEM-CELLS; GERM-LINE TRANSMISSION; T-CELLS; INTRAEPITHELIAL LYMPHOCYTES; RECOMBINANT INTERLEUKIN-2; PERIPHERAL-BLOOD; GUT EPITHELIUM; HPRT GENE; EXPRESSION;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 42
- Recensione:
- Indirizzi per estratti:
-
-
-
- Citazione:
- B. Sadlack et al., "ULCERATIVE COLITIS-LIKE DISEASE IN MICE WITH A DISRUPTED INTERLEUKIN-2 GENE", Cell, 75(2), 1993, pp. 253-261
Abstract
Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similarity to ulcerative colitis in humans. The alterations of the immune system are characterized by a highnumber of activated T and B cells, elevated immunoglobin secretion, anti-colon antibodies, and aberrant expression of class II major histocompatibility complex molecules. The data provide evidence for a primary role of the immune system in the etiology of ulcerative colitis and strongly suggest that the disease results from an abnormal immune response to a normal antigenic stimulus.
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Documento generato il 28/11/20 alle ore 15:35:27