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Titolo:
11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN MESENTERIC-ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
TAKEDA Y; YONEDA T; MIYAMORI I; GATHIRAM P; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN UNIV NATAL,SCH MED,DEPT PHYSIOL DURBAN SOUTH AFRICA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 10, volume: 20, anno: 1993,
pagine: 627 - 631
SICI:
0305-1870(1993)20:10<627:1DIMO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; MINERALOCORTICOID ACTIVITY; PRESSOR RESPONSIVENESS; GLUCOCORTICOIDS; BINDING; PATHOGENESIS; LIQUORICE; RECEPTOR; CYTOSOL; HUMANS;
Keywords:
GLUCOCORTICOID; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; MESENTERIC ARTERY; NOREPINEPHRINE; SHR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN MESENTERIC-ARTERIES OF SPONTANEOUSLY HYPERTENSIVE RATS", Clinical and experimental pharmacology and physiology, 20(10), 1993, pp. 627-631

Abstract

1. 11beta-Hydroxysteroid dehydrogenase (11-HSD) activity in mesenteric arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was determined and expressed as the percentage conversion of[H-3]-corticosterone to [H-3]-11-dehydrocorticosterone. 2. 11-HSD activity was significantly decreased in mesenteric arteries of both 4 and9 week old SHR (8.4 +/- 0.8%, 5.0 +/- 1.5%, respectively) compared with WKY rats (12.4 +/- 0.6%, 15.8 +/- 0.7%, respectively; P < 0.05). 3. Total RNA from rat vascular smooth muscle cells (VSMC) and endothelial cells (EC) were prepared with selective precipitation in 3 mol/L LiCl/6 mol/L urea. The expression of 11-HSD mRNA was confirmed in the ratVSMC but its mRNA expression was not detected in EC, using northern blot analysis. 4. The results in this study indicate that 11-HSD in thevascular wall may play a role in the pathogenesis of hypertension in SHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:13:32