Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT AND CONTENT OF ARGININE-VASOPRESSIN IN NORMAL AND OBSTRUCTED RAT URINARY-BLADDER - AN IN-VIVO AND IN-VITRO INVESTIGATION
Autore:
BERGGREN T; ANDERSSON KE; LUNDIN S; UVELIUS B;
Indirizzi:
UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN
Titolo Testata:
The Journal of urology
fascicolo: 5, volume: 150, anno: 1993,
parte:, 1
pagine: 1540 - 1543
SICI:
0022-5347(1993)150:5<1540:EACOAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFRAVESICAL OUTFLOW OBSTRUCTION; SMOOTH-MUSCLE; DETRUSOR; RABBIT;
Keywords:
BLADDER; RATS; VASOPRESSINS; BLADDER NECK OBSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T. Berggren et al., "EFFECT AND CONTENT OF ARGININE-VASOPRESSIN IN NORMAL AND OBSTRUCTED RAT URINARY-BLADDER - AN IN-VIVO AND IN-VITRO INVESTIGATION", The Journal of urology, 150(5), 1993, pp. 1540-1543

Abstract

The present investigation was performed to evaluate the possible roleof arginine vasopressin (AVP) in detrusor instability in the obstructed rat urinary bladder. The effect of AVP on normal and obstructed ratdetrusor smooth muscle was tested in vivo and in vitro. Arginine vasopressin given as a closed intraarterial injection to the bladder transiently decreased micturition volume and increased micturition frequency during cystometry in control rats. In rats with infravesical outlet obstruction the effect of AVP on cystometrical parameters was negligible. In accordance with this finding, the efficacy of AVP in contracting detrusor muscle in vitro was much lower for obstructed bladders thanfor controls. The EC50 values were, however, similar. Arginine vasopressin added to the bath had no effect on nerve-mediated contractile responses. Obstruction led to a transient decrease in immunoreactive AVPconcentration, but the total amount of AVP per bladder increased significantly after 6 weeks of obstruction as a consequence of the 14-foldincrease in bladder weight. The decreased excitatory effect of AVP inobstructed bladder makes a role for this peptide in the development of detrusor instability less likely.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:41:30