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Titolo:
PATTERNS OF FAILURE AFTER TRIMODALITY THERAPY FOR MALIGNANT PLEURAL MESOTHELIOMA
Autore:
BALDINI EH; RECHT A; STRAUSS GM; DECAMP MM; SWANSON SJ; LIPTAY MJ; MENTZER SJ; SUGARBAKER DJ;
Indirizzi:
BRIGHAM & WOMENS HOSP,JOINT CTR RADIAT THERAPY,75 FRANCIS ST BOSTON MA 02115 DANA FARBER CANC INST,JOINT CTR RADIAT THERAPY,DIV MED ONCOL BOSTON MA 02115 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV THORAC SURG BOSTON MA 02115
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 2, volume: 63, anno: 1997,
pagine: 334 - 338
SICI:
0003-4975(1997)63:2<334:POFATT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRAPLEURAL PNEUMONECTOMY; MULTIMODALITY THERAPY; DIFFUSE; MANAGEMENT; EXPERIENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E.H. Baldini et al., "PATTERNS OF FAILURE AFTER TRIMODALITY THERAPY FOR MALIGNANT PLEURAL MESOTHELIOMA", The Annals of thoracic surgery, 63(2), 1997, pp. 334-338

Abstract

Background. Malignant pleural mesothelioma is uncommon, and presently, no standard treatment of this disease exists. The objective of our analysis was to study the patterns of failure for malignant pleural mesothelioma after trimodality treatment consisting of extrapleural pneumonectomy, chemotherapy, and radiation therapy. Methods. Between 1987 and 1993, 49 patients with malignant pleural mesothelioma underwent extrapleural pneumonectomy. There were two perioperative deaths, and 1 patient died 5 weeks after extrapleural pneumonectomy. Thirty-five of the surviving patients received adjuvant chemotherapy (32/35 received cyclophosphamide, doxorubicin, and cisplatin) followed by hemithorax radiation therapy. Ten patients received chemotherapy but no radiation therapy, and 1 patient received no adjuvant therapy. Median follow-up time for the 23 living patients from the date of operation was 18 months. Results. Of the 46 evaluable patients, 25 had recurrence (54%), witha median time to first failure of 19 months (range, 5 to 51 months). The sites of first recurrence were local in 35% of patients, abdominalin 26%, the contralateral thorax in 17%, and other distant sites in 8%, (Some patients had recurrence in multiple sites simultaneously). Conclusions. The most common site of failure after trimodality therapy was the ipsilateral hemithorax. Isolated distant failures were uncommon. Future strategies should investigate methods of enhancing local tumor control. (C) 1997 by The Society of Thoracic Surgeons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:16:29