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Titolo:
STRUCTURAL SYNAPTIC CORRELATE OF LONG-TERM POTENTIATION - FORMATION OF AXOSPINOUS SYNAPSES WITH MULTIPLE, COMPLETELY PARTITIONED TRANSMISSION ZONES
Autore:
GEINISMAN Y; DETOLEDOMORRELL L; MORRELL F; HELLER RE; ROSSI M; PARSHALL RF;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT CELL MOLEC & STRUCT BIOL,303 E CHICAGOAVE CHICAGO IL 60611 RUSH MED COLL,DEPT NEUROL SCI CHICAGO IL 60612 RUSH MED COLL,DEPT PSYCHOL CHICAGO IL 60612 UNIV ILLINOIS,DEPT BIOMED VISUALIZAT CHICAGO IL 60680
Titolo Testata:
Hippocampus
fascicolo: 4, volume: 3, anno: 1993,
pagine: 435 - 446
SICI:
1050-9631(1993)3:4<435:SSCOLP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEGMENTED POSTSYNAPTIC DENSITIES; RABBIT FOLLOWING STIMULATION; HIPPOCAMPAL DENTATE GYRUS; LASTING POTENTIATION; PERFORATED SYNAPSES; ARBITRARY PARTICLES; RAT HIPPOCAMPUS; DENDRITIC SPINE; NERVOUS-SYSTEM; SERIAL-SECTION;
Keywords:
STRUCTURAL SYNAPTIC PLASTICITY; HIPPOCAMPAL DENTATE GYRUS; PERFORATED SYNAPSES; SYNAPSE QUANTITATION; DENDRITIC SPINES; 3-DIMENSIONAL RECONSTRUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
Y. Geinisman et al., "STRUCTURAL SYNAPTIC CORRELATE OF LONG-TERM POTENTIATION - FORMATION OF AXOSPINOUS SYNAPSES WITH MULTIPLE, COMPLETELY PARTITIONED TRANSMISSION ZONES", Hippocampus, 3(4), 1993, pp. 435-446

Abstract

Synapses were analyzed in the middle molecular layer (MML) and inner molecular layer (IML) of the rat dentate gyrus following the inductionof long-term potentiation (LTP) by high-frequency stimulation of the medial perforant path carried out on each of 4 consecutive days. Potentiated animals were sacrificed 1 hour after the fourth high frequency stimulation. Stimulated but not potentiated and implanted but not stimulated animals served as controls. Using the stereological disector technique, unbiased estimates of the number of synapses per postsynapticneuron were differentially obtained for various subtypes of axospinous junctions: For atypical (giant) nonperforated synapses with a continuous postsynaptic density (PSD), and for perforated ones distinguishedby (1) a fenestrated PSD and focal spine partition, (2) a horseshoe-shaped PSD and sectional spine partition, (3) a segmented PSD and complete spine partition(s), and (4) a fenestrated, (5) horseshoe-shaped, or (6) segmented PSD without a spine partition. The major finding of this study is that the induction of LTP in the rat dentate gyrus is followed by a significant and marked increase in the number of only those perforated axospinous synapses that have multiple, completely partitioned transmission zones. No other synaptic subtype exhibits such a change as a result of LTP induction. Moreover, this structural alteration is limited to the terminal synaptic field of activated axons (MML) anddoes not involve an immediately adjacent one (IML) that was not directly activated by potentiating stimulation. The observed highly selective modification of synaptic connectivity involving only one particularsynaptic subtype in the potentiated synaptic field may represent a structural substrate of the long-lasting enhancement of synaptic responses that characterizes LTP.

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Documento generato il 02/12/20 alle ore 18:33:59