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Titolo:
PLASMINOGEN-ACTIVATOR ACTIVITY IN PREVULATORY FOLLICLES DURING THE OVULATORY CYCLE OF THE CHICKEN
Autore:
JACKSON JA; ZHANG P; BAHR JM;
Indirizzi:
ANIM SCI LAB 326,1207 W GREGORY ST URBANA IL 61801 UNIV ILLINOIS,DEPT ANIM SCI URBANA IL 61801
Titolo Testata:
Biology of reproduction
fascicolo: 5, volume: 49, anno: 1993,
pagine: 1141 - 1146
SICI:
0006-3363(1993)49:5<1141:PAIPFD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUMULUS-OOCYTE COMPLEXES; TISSUE-TYPE; PERIOVULATORY PERIOD; GRANULOSA-CELLS; OVARIAN FOLLICLE; DOMESTIC HEN; RAT GRANULOSA; BIOSYNTHESIS; INHIBITOR; THECA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Jackson et al., "PLASMINOGEN-ACTIVATOR ACTIVITY IN PREVULATORY FOLLICLES DURING THE OVULATORY CYCLE OF THE CHICKEN", Biology of reproduction, 49(5), 1993, pp. 1141-1146

Abstract

The stages of follicular maturation of a preovulatory follicle in thechicken can be divided into an extended proliferative phase (prior tothe LH surge) and a brief ovulatory phase (after the LH surge). Thereis evidence to suggest that plasminogen activator (PA) may play a role in follicular maturation and ovulation in the chicken. The objectiveof this study was to determine whether PA activity changes in the stigma (site of follicular rupture) and nonstigma regions of the theca layer, granulosa layer, and germinal disc region (germinal disc and adjacent granulosa cells; GDR) during the transition from the proliferative phase to the ovulatory phase and immediately before ovulation. The largest preovulatory follicle (F1) and the second-largest follicle (F2), which would have ovulated first and 26 h later, respectively, were collected at 8 h and 2 h before ovulation (before and after the LH surge, respectively), and at 0.5 h (immediately before ovulation). PA activity in the stigma region of the theca layer in the F1 and F2 follicles was very low at 8 h before ovulation (before the LH surge) and increased dramatically (9-fold) at 2 h before ovulation (after the LH surge). PA activity in the stigma region of the F1 follicles remained high as the follicles prepared to ovulate (0.5 h before ovulation), whereasin the stigma region of the less mature F2 follicles it decreased to a level similar to that measured 8 h before ovulation. PA activity in the nonstigma region of the theca layer and peripheral granulosa layerof the F1 follicles showed an increase at 2 h before ovulation compared to activity at 8 h and then decreased immediately before ovulation to the same level as before the LH surge (8 h before ovulation). Therewas abundant PA activity in the GDR of F1 follicles at 8 h before ovulation, 30- and 200-fold higher than the PA activity in theca and granulosa layers, respectively. However, PA activity in the F1 and F2 GDRsdecreased precipitously after the LH surge and remained low as ovulation of the F1 follicles approached. In conclusion, the dramatic and specific increase in PA activity in the F1 stigma region after the LH surge and its sustained elevation as the F1 follicles approached ovulation suggests that PA may have a role in the ovulatory process in the chicken. In contrast, the high concentration of PA activity in the GDR, which was suppressed after the LH surge, suggests that PA production by the GDR may be involved in follicular growth and maturation.

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Documento generato il 05/07/20 alle ore 06:19:16