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Titolo:
ULTRASOUND-ASSISTED THROMBOLYSIS
Autore:
SEHGAL CM; LEVEEN RF; SHLANSKYGOLDBERG RD;
Indirizzi:
UNIV PENN,DEPT RADIOL,308 STEMMLER HALL,36TH & HAMILTON WALK PHILADELPHIA PA 19104 HOSP UNIV PENN PHILADELPHIA PA 19104 VET ADM MED CTR OMAHA NE 68105
Titolo Testata:
Investigative radiology
fascicolo: 10, volume: 28, anno: 1993,
pagine: 939 - 943
SICI:
0020-9996(1993)28:10<939:UT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIES; ANGIOPLASTY; UROKINASE; THROMBI; INVITRO;
Keywords:
ULTRASONICS; THROMBOLYSIS; THROMBOLYTIC AGENTS; UROKINASE CLOTLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Sehgal et al., "ULTRASOUND-ASSISTED THROMBOLYSIS", Investigative radiology, 28(10), 1993, pp. 939-943

Abstract

RATIONALE AND OBJECTIVES. Current use of thrombolytic agents to lyse thrombus, though safe, is complicated by stroke, bleeding, and clot embolization. Therapy may be protracted, resulting in further ischemia and possible tissue loss. Peripheral arterial and graft occlusions often require several hours of thrombolytic therapy, which may occasionally exceed 48 hours and may also require expensive intensive care monitoring. It is desirable to accelerate clot lysis and to thereby reduce the risks and costs associated with the procedure and minimize morbidity. In this article, the authors propose the use of intravascular ultrasound in conjunction with thrombolytic agents to increase the rate of thrombolysis. METHODS AND RESULTS. In-vitro thrombolysis of fresh human blood clots was studied with and without urokinase by using continuous wave, 20-KHz ultrasound at the power levels 1-2 watts. Loss in weight of each clot was used to measure the extent of thrombolysis. Clot lysis was observed when ultrasound and thrombolytic agents were used alone. At modest power levels of 1.0 to 1.5 watts of ultrasonic energy asignificant increase in lysis was observed in conjunction with 5,000 units of urokinase. CONCLUSIONS. In the short treatment duration of this in-vitro study, 5,000 units of urokinase combined with 20-KHz ultrasound energy at 1.0 and 1.5 watts was associated with a greater percentage thrombolysis by weight than either urokinase or ultrasound alone.

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Documento generato il 01/12/20 alle ore 08:10:59