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Titolo:
MULTIPLE SQUAMOUS-CELL CARCINOMAS IN A PSORIATIC PATIENT FOLLOWING HIGH-DOSE PHOTOCHEMOTHERAPY AND CYCLOSPORINE TREATMENT - RESPONSE TO LONG-TERM ACITRETIN MAINTENANCE
Autore:
VANDEKERKHOF PCM; DEROOIJ MJM;
Indirizzi:
UNIV NIJMEGEN HOSP,DEPT DERMATOL,POB 9101 NL-6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
British journal of dermatology
fascicolo: 2, volume: 136, anno: 1997,
pagine: 275 - 278
SICI:
0007-0963(1997)136:2<275:MSCIAP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAVIOLET-RADIATION; SKIN-CANCER; THERAPY; PUVA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
P.C.M. Vandekerkhof e M.J.M. Derooij, "MULTIPLE SQUAMOUS-CELL CARCINOMAS IN A PSORIATIC PATIENT FOLLOWING HIGH-DOSE PHOTOCHEMOTHERAPY AND CYCLOSPORINE TREATMENT - RESPONSE TO LONG-TERM ACITRETIN MAINTENANCE", British journal of dermatology, 136(2), 1997, pp. 275-278

Abstract

Cumulative toxicity is a well known limitation of antipsoriatic treatments. In particular, the induction of multiple squamous cell carcinomas following long-term PUVA treatment is well established. In the present report, a psoriatic patient is described who was treated for more than 14 years with photochemotherapy (PUVA) and who received excessiveamounts of topical corticosteroids. The patient developed, in total, 34 squamous cell carcinomas. In all, three squamous cell carcinomas developed during long-term PUVA treatment, and 21 carcinomas appeared during 16 months of treatment with cyclosporin. Subsequently, a marked inhibition of the occurrence of new tumours occurred during prolonged treatment with acitretin, and no new tumours have appeared during the last 4 years of continuous treatment with this retinoid at a dose of 60mg/day. Modulation of the expression of PUVA-induced squamous cell carcinomas by cyclosporin and acitretin are discussed. The present report lends support to the hypothesis that cyclosporin causes an increasedoccurrence of PUVA-induced carcinomas, whereas acitretin (60 mg/day) is of value in preventing the occurrence of new squamous cell carcinomas in patients who were treated with longterm PUVA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/10/20 alle ore 12:50:33