Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYTOKINE PRODUCTION IN THE BRAIN FOLLOWING CLOSED-HEAD INJURY - DEXANABINOL (HU-211) IS A NOVEL TNF-ALPHA INHIBITOR AND AN EFFECTIVE NEUROPROTECTANT
Autore:
SHOHAMI E; GALLILY R; MECHOULAM R; BASS R; BENHUR T;
Indirizzi:
HEBREW UNIV JERUSALEM,SCH PHARM,DEPT PHARMACOL IL-91120 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT IMMUNOL IL-91010 JERUSALEM ISRAEL HEBREW UNIV JERUSALEM,SCH PHARM,DEPT NAT PROD IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Journal of neuroimmunology
fascicolo: 2, volume: 72, anno: 1997,
pagine: 169 - 177
SICI:
0165-5728(1997)72:2<169:CPITBF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NONCOMPETITIVE NMDA ANTAGONIST; RAT-BRAIN; CEREBRAL-ISCHEMIA; ASPARTATE; RECEPTOR; MECHANISMS; ACID; DAMAGE; MICRODIALYSIS;
Keywords:
BLOOD-BRAIN BARRIER; CLOSED HEAD INJURY; DEXANABINOL (HU-211); EDEMA; TUMOR NECROSIS FACROR-ALPHA (TNF-ALPHA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
E. Shohami et al., "CYTOKINE PRODUCTION IN THE BRAIN FOLLOWING CLOSED-HEAD INJURY - DEXANABINOL (HU-211) IS A NOVEL TNF-ALPHA INHIBITOR AND AN EFFECTIVE NEUROPROTECTANT", Journal of neuroimmunology, 72(2), 1997, pp. 169-177

Abstract

Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and impaired function. Harmful mediators are accumulating in the brain after injury and recently, the role of cytokines in the pathophysiology of brain injury has been suggested. We have developed an experimental model for closed head injury (CHI), in which edema, blood-brain-barrier disruption, motor and memory dysfunctions have been demonstrated. In this study, spatial and temporal induction of IL-1, IL-6 and TNF-alpha gene mRNA transcription and of TNF-alpha and IL-6 activity in rat brain after CHI are shown. Dexanabinol, HU-211, is a synthetic cannabinoid devoid of cannabimimetic effects; it exhibits pharmacological properties of N-methyl-D-aspartate (NMDA)-receptor antagonist and is an effective cerebroprotecant. We report here that HU-211 is a novel inhibitor of TNF-alpha production at a post-transcriptional stage. HU-211, pentoxyfilline and TNF-binding protein improved the outcome of CHI. We suggest that TNF-alpha is a primary mediator of neurotoxicity after CHI, as inhibition of TNF-alpha is associated withbetter clinical recovery. TNF-alpha modulating agents, if given within the early time window post-injury, may improve the final neurological outcome in victims of brain trauma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:29:19