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Titolo:
INFLUENCE OF CELL-DENSITY AND RECEPTOR NUMBER ON THE BINDING AND DISTRIBUTION OF CELL-SURFACE EPIDERMAL GROWTH-FACTOR RECEPTORS
Autore:
KUSZYNSKI CA; MILLER KA; RIZZINO A;
Indirizzi:
EPPLEY INST RES CANC & ALLIED DIS,600 S 42ND ST OMAHA NE 68198 EPPLEY INST RES CANC & ALLIED DIS,600 S 42ND ST OMAHA NE 68198 UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL OMAHA NE 68198
Titolo Testata:
In vitro cellular & developmental biology. Animal
fascicolo: 9, volume: 29, anno: 1993,
pagine: 708 - 713
SICI:
1071-2690(1993)29:9<708:IOCARN>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIRECT VISUALIZATION; INTERNALIZATION; CULTURE; LINES;
Keywords:
CELL DENSITY; DENSITY INDUCED DOWN REGULATION; EPIDERMAL GROWTH FACTOR RECEPTOR; IMAGE ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Kuszynski et al., "INFLUENCE OF CELL-DENSITY AND RECEPTOR NUMBER ON THE BINDING AND DISTRIBUTION OF CELL-SURFACE EPIDERMAL GROWTH-FACTOR RECEPTORS", In vitro cellular & developmental biology. Animal, 29(9), 1993, pp. 708-713

Abstract

Previous studies have shown that cell density influences the expression of receptors for at least four growth factors. The data presented in this report demonstrate that epidermal growth factor receptors are regulated differently on cells expressing over a million receptors as opposed to cells expressing approximately fivefold fewer receptors. Specifically, we show that BT-20, MDA-468, and A-431-RI cells, which exhibit a large number of epidermal growth factor receptors, preferentially down-regulate the high affinity class of these receptors as cell density increases. In addition, we show that these cells express cell surface epidermal growth factor receptors that are localized predominately to the periphery of the cells. In contrast, A-549 and BSC-1 cells, which exhibit fewer cell surface epidermal growth factor receptors and which reduce all affinity classes of epidermal growth factor receptorsas cell density increases, exhibit a diffuse cell surface distribution of these receptors at both low and high densities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:23:39