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Titolo:
EFFECTS OF SENNOSIDES AND NONANTHRANOID LAXATIVES ON CYTOCHEMISTRY OFEPITHELIAL-CELLS IN RAT COLON
Autore:
YANG K; FAN K; MENGS U; LIPKIN M;
Indirizzi:
MEM SLOAN KETTERING CANC CTR,DEPT MED,GASTROENTEROL & NUTR SERV,BOX 70,1275 YORK AVE NEW YORK NY 10021 MADAUS AG,DEPT TOXICOL & EXPTL PATHOL COLOGNE GERMANY
Titolo Testata:
Pharmacology
, volume: 47, anno: 1993, supplemento:, 1
pagine: 196 - 204
SICI:
0031-7012(1993)47:<196:EOSANL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCUS SECRETION; LARGE-INTESTINE; CHRYSAZIN;
Keywords:
SENNOSIDES; BISACODYL; PICOSULFATE; COLON; ACIDIC MUCINS; CYTOKERATIN; LECTIN SOYBEAN AGGLUTININ; IMMUNOHISTOCHEMISTRY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K. Yang et al., "EFFECTS OF SENNOSIDES AND NONANTHRANOID LAXATIVES ON CYTOCHEMISTRY OFEPITHELIAL-CELLS IN RAT COLON", Pharmacology, 47, 1993, pp. 196-204

Abstract

The cytochemical effects of laxatives on rat colonic epithelial cellswere studied. A total of 32 rats was divided into four groups. Three groups were treated with bisacodyl, picosulfate and sennosides for 12 weeks, and a fourth group served as control. The rectum, midcolon and cecum were studied for acidic mucins, lectin soybean agglutinin (SBA) and cytokeratin AE1. Most striking and consistent changes were found in the rectum including total acidic mucin content which significantly increased, with sulfomucin decreased and sialomucin increased in the three treatment groups. Cytokeratin AE1 expression increased on picosulfate and sennosides. SBA total binding increased on bisacodyl and picosulfate. The present findings were thought to be of functional origin and do not represent early precancerous lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:19:26