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Titolo:
EFFECTS OF CONTACT LAXATIVES ON INTESTINAL AND COLONIC EPITHELIAL-CELL PROLIFERATION
Autore:
GEBOES K; NIJS G; MENGS U; GEBOES KPJ; VANDAMME A; DEWITTE P;
Indirizzi:
KATHOLIEKE UNIV LEUVEN,DEPT MED RES,HISTO & CYTOCHEM LAB,MINDERBROEDERSSTR 12 B-3000 LOUVAIN BELGIUM KATHOLIEKE UNIV LEUVEN,INST PHARMACEUT SCI,PHARMACEUT BIOL & PHYTOPHARMACOL LAB LOUVAIN BELGIUM MADAUS AG,DEPT TOXICOL COLOGNE GERMANY
Titolo Testata:
Pharmacology
, volume: 47, anno: 1993, supplemento:, 1
pagine: 187 - 195
SICI:
0031-7012(1993)47:<187:EOCLOI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL MUCOSA; BROMODEOXYURIDINE; PROSTAGLANDINS; INVIVO; CANCER; COLI; RAT;
Keywords:
SENNOSIDES; BROMODEOXYURIDINE; BISACODYL; LACTULOSE; SODIUM PICOSULFATE; EPITHELIAL CELL PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Geboes et al., "EFFECTS OF CONTACT LAXATIVES ON INTESTINAL AND COLONIC EPITHELIAL-CELL PROLIFERATION", Pharmacology, 47, 1993, pp. 187-195

Abstract

Experimental studies indicate that laxatives may induce epithelial damage. In addition, some laxatives induce the release of prostaglandins. Epithelial cell damage and release of prostaglandins are two pathways by which epithelial cell proliferation could be influenced. Furthermore, fermentable laxatives like lactulose may influence large intestine cell proliferation by the trophic effect of the fermentation products such as short-chain fatty acids. For these reasons an in vivo study in rats was performed to compare the short- and long-term effect of sennosides, bisacodyl, sodium picosulfate and lactulose on epithelial cell proliferation in the ileum and large intestine. Cell proliferation was examined by the BrdUrd labelling technique after 2, 6 and 12 weeksof continuous treatment. Studies in control animals show that the Labeling Index (LI) is higher in the cecum compared with other segments of the colon, and higher in the ileum than in the colon. Treatment withsennosides, bisacodyl and sodium picosulfate does not influence the LI in the ileum and induces no statistically significant increase of the LI when the treated groups are compared with the control group. The proliferative pattern along the crypts remains unchanged with all the laxatives throughout the study. It appears therefore that 'contact' laxatives have no major influence on ileal and colonic epithelial cell proliferation and should not be regarded as tumor-promoting substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:14:44