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Titolo:
THE GENOTOXICITY STATUS OF SENNA
Autore:
HEIDEMANN A; MILTENBURGER HG; MENGS U;
Indirizzi:
MADAUS AG,TOXIKOL ABT,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY TH DARMSTADT,MUTAGENITATSPRUFUNG LAB W-6100 DARMSTADT GERMANY CCR CYTOTEST CELL RES ROSSDORF GERMANY
Titolo Testata:
Pharmacology
, volume: 47, anno: 1993, supplemento:, 1
pagine: 178 - 186
SICI:
0031-7012(1993)47:<178:TGSOS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TOX PROGRAM; MUTAGENICITY; CHRYSAZIN; INVIVO; LIVER; GUIDE; ASSAY; MICE;
Keywords:
SENNA; ANTHRAQUINONES; GENOTOXICITY; EVALUATION OF GENOTOXICITY DATA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A. Heidemann et al., "THE GENOTOXICITY STATUS OF SENNA", Pharmacology, 47, 1993, pp. 178-186

Abstract

Genotoxicity tests were performed by several laboratories with the drug fructus sennae, senna extract, sennosides, rhein and aloe-emodin. The drug fructus sennae, the sennosides and rhein did not increase mutation frequencies in the following test systems: bacterial systems (Salmonella reverse mutation test and/or Escherichia coli forward mutationtest); mammalian cell cultures [hypoxanthine guanine phosphoribosyl transferase (HGPRT) test; mouse lymphoma test; chromosome aberration test with Chinese hamster ovary cells]; bone marrow (micronucleus test; chromosome aberration test); melanoblast cells (mouse spot test) of rodents. With aloe-emodin mutagenic effects were observed only in vitro in the chromosome aberration test with CHO cells and in the Salmonellareverse mutation test (frameshift mutations in strains TA 1537, TA 1538 and TA 98). In the in vitro gene mutation test with V79 cells (HGPRT test) no mutagenic potential of aloe-emodin was observed. In in vivostudies [micronucleus test with bone marrow cells of NMRI mice, chromosome aberration test with bone marrow cells of Wistar rats, mouse spot test (crossing DBA/2J x NMRI) no indication for a mutagenic activityof aloe-emodin was found. The relevance of the absence of a mutagenicpotential in in vivo test systems was strengthened by the fact that aloe-emodin could be found in the blood serum after oral administration. Additional information on the interaction of aloe-emodin with DNA was obtained from an ex vivo unscheduled DNA synthesis test performed with hepatocytes of male Wistar rats: aloe-emodin did not induce unscheduled DNA synthesis as expression of DNA damage. The extract of senna induced gene mutations in bacteria (frame shift mutations in TA 1537 and TA 98), but a negative result was obtained in the gene mutation testwith V79 cells (HGPRT test). In the chromosome aberration test with CHO cells the senna extract induced structural chromosomal aberrations. The results demonstrate that an extract of senna and aloe-emodin weregenotoxic when tested with some in vitro test systems. Under in vivo conditions so far no genotoxic effect was found. The drug fructus sennae, the sennosides and rhein were negative under in vitro as well as under in vivo conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:09:50