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Titolo:
CLEAVAGES OF THE O-GLUCOSYL AND C-GLUCOSYL BONDS OF ANTHRONE AND 10,10'-BIANTHRONE DERIVATIVES BY HUMAN INTESTINAL BACTERIA
Autore:
HATTORI M; AKAO T; KOBASHI K; NAMBA T;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,2630 SUGITANI TOYAMA93010 JAPAN TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI TOYAMA 93010 JAPAN
Titolo Testata:
Pharmacology
, volume: 47, anno: 1993, supplemento:, 1
pagine: 125 - 133
SICI:
0031-7012(1993)47:<125:COTOAC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYMATIC REDUCTION; METABOLISM; SENNOSIDES; BARBALOIN; ALOE;
Keywords:
SENNOSIDE; BARBALOIN; HUMAN INTESTINAL BACTERIA; BIFIDOBACTERIUM SP; EUBACTERIUM SP; BETA-GLUCOSIDASE; C-GLUCOSIDASE; PRODRUG; LAXATIVE; NOJIRIMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Hattori et al., "CLEAVAGES OF THE O-GLUCOSYL AND C-GLUCOSYL BONDS OF ANTHRONE AND 10,10'-BIANTHRONE DERIVATIVES BY HUMAN INTESTINAL BACTERIA", Pharmacology, 47, 1993, pp. 125-133

Abstract

A strictly anaerobic bacterium, Bifidobacterium sp. SEN, capable of hydrolyzing the O-glucosyl of sennosides was isolated from human feces. The bacterium stepwisely hydrolyzed sennoside B to sennidin B throughsennidin-8-monoglucoside in PYF medium but not in GAM broth. Additionof D-glucose to PYF medium resulted in loss of the hydrolyzing activity in culture but addition of D-fructose did not affect the activity. Coculture of this bacterium with Peptostreptococcus intermedius led torapid accumulation of rhein anthrone in the medium. Similarly, a bacterium, Eubacterium sp. BAR, capable of cleaving the C-glucosyl of barbaloin was isolated from human feces. This bacterium grew in PYF mediumcontaining barbaloin and produced enzyme(s) that cleave(s) the C-glucosyl. The induction of the enzymes was completely inhibited in the presence of D-glucose. Nojirimycin inhibited the enzyme activity induced by barbaloin but it did not inhibit the bacterial growth in the presence of D-glucose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:39:48