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Titolo:
METABOLISM AND PHARMACOKINETICS OF ANTHRANOIDS
Autore:
DEWITTE P;
Indirizzi:
KATHOLIEKE UNIV LEUVEN,FARMACEUT BIOL & FYTOFARMACOL LAB,VAN EVENSTR 4 B-3000 LOUVAIN BELGIUM
Titolo Testata:
Pharmacology
, volume: 47, anno: 1993, supplemento:, 1
pagine: 86 - 97
SICI:
0031-7012(1993)47:<86:MAPOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL BACTERIA; RHEIN ANTHRONE; ANTHRAQUINONE LAXATIVES; ENZYMATIC REDUCTION; RAT; SENNOSIDES; INVITRO; DERIVATIVES; MICROFLORA; DRUGS;
Keywords:
METABOLISM; PHARMACOKINETICS; SENNOSIDES; RHEIN; ANTHRANOID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Dewitte, "METABOLISM AND PHARMACOKINETICS OF ANTHRANOIDS", Pharmacology, 47, 1993, pp. 86-97

Abstract

Anthranoid derivatives are used all over the world as a treatment forconstipation. These compounds are present in several drugs of plant origin, especially as O- or C-glycosides. Besides featuring different substituents, the aglycone might consist of an anthraquinone, an anthrone or a dianthrone. So far, detailed information concerning their metabolism and pharmacokinetic characteristics is available only in a few cases. The best characterized compounds are sennoside, a dianthrone O-glycoside present in senna leaves and senna pods, and its aglycone (rhein anthrone). After oral administration, sennoside is degraded only in the lower parts of the gastrointestinal tract, releasing its active metabolite rhein anthrone. Nowadays, this process is understood at themolecular level. A study with C-14-labelled rhein anthrone administered intracecally to rats, revealed that the compound is scarcely absorbed. Since on the contrary its anthraquinone equivalent is absorbed to a much larger extent, it is inferred that dianthrone- or anthrone-glycosides exhibit a lower systemic availability than anthraquinone O-glycosides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:37:06