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Titolo:
ENDOGENOUS DIGITALIS-LIKE ACTIVITY IN THE NEWBORN
Autore:
GHIONE S; BALZAN S; DECOLLOGNE S; PACI A; PIERACCINI L; MONTALI U;
Indirizzi:
CNR,INST CLIN PHYSIOL,VIA SAVI 8 I-56100 PISA ITALY UNIV PISA,IST CHIM BIOL I-56100 PISA ITALY LAB PHARMACOL,HALL BIOTECHNOL PARIS FRANCE
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 22, anno: 1993, supplemento:, 2
pagine: 190000025 - 190000028
SICI:
0160-2446(1993)22:<190000025:EDAITN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIGOXIN-LIKE IMMUNOREACTIVITY; FULL-TERM INFANTS; HUMAN-PLASMA; CORD BLOOD; URINARY ELECTROLYTES; SERUM; SUBSTANCE; EXTRACTS; IDENTIFICATION; CHROMATOGRAPHY;
Keywords:
ENDOGENOUS DIGOXIN-LIKE IMMUNOREACTIVITY; NEWBORNS; BODY FLUIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Ghione et al., "ENDOGENOUS DIGITALIS-LIKE ACTIVITY IN THE NEWBORN", Journal of cardiovascular pharmacology, 22, 1993, pp. 190000025-190000028

Abstract

Elevated levels of endogenous digoxin-like immunoreactivity have beenreported in the body fluids of premature and full-term infants as well as in term pregnancy, in the amniotic fluid, and in human milk. Several lines of evidence suggest that these factors could also have biological properties in common with digitalis: i.e., they could represent truly endogenous digitalis-like factor(s). In recent years we succeeded in partially purifying this factor from umbilical cord blood, which represents an easily available source of this factor. The inhibitory activity of this factor on Rb-86 uptake could be neutralized by antidigoxin antibodies (Fab fragments) and provided, for the first time, direct evidence of an association between digoxin-like immunoreactivity and biological digitalis-like activity. In addition, these antibodies could be used for immunoaffine chromatography as a purification step before separation by high-performance liquid chromatography. Preliminary experiments suggest that this endogenous compound has both a tissue and an isoenzyme selectivity and is not a well-known steroid (testosterone, progesterone, 17-OH progesterone, cortisol, dehydroepiandrosteronesulfate, and estradiol).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:56:02