Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEGATIVE AUTOREGULATION OF C-MYB ACTIVITY BY HOMODIMER FORMATION THROUGH THE LEUCINE-ZIPPER
Autore:
NOMURA T; SAKAI N; SARAI A; SUDO T; KANEIISHII C; RAMSAY RG; FAVIER D; GONDA TJ; ISHII S;
Indirizzi:
RIKEN,TSUKUBA LIFE SCI CTR TSUKUBA IBARAKI 305 JAPAN ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES,MELBOURNE TUMOUR BIOL BRANCH PARKVILLE VIC 3050 AUSTRALIA INST MED & VET SCI,HANSON CTR CANC RES ADELAIDE SA 5000 AUSTRALIA
Titolo Testata:
The Journal of biological chemistry
fascicolo: 29, volume: 268, anno: 1993,
pagine: 21914 - 21923
SICI:
0021-9258(1993)268:29<21914:NAOCAB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING DOMAIN; PROTO-ONCOGENE PRODUCT; B-CELL LYMPHOMAS; V-MYB; MYELOMONOCYTIC CELLS; GLUCOCORTICOID RECEPTOR; CONSTITUTIVE EXPRESSION; NUCLEOTIDE-SEQUENCE; MYELOID-LEUKEMIA; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
T. Nomura et al., "NEGATIVE AUTOREGULATION OF C-MYB ACTIVITY BY HOMODIMER FORMATION THROUGH THE LEUCINE-ZIPPER", The Journal of biological chemistry, 268(29), 1993, pp. 21914-21923

Abstract

The trans-activating and transforming capacities of the c-myb proto-oncogene product (c-Myb) are negatively regulated through a leucine zipper structure in its negative regulatory domain. We show here that in contransfection assays, maximal Myb-induced trans-activation occurs with relatively low amounts of wild-type c-Myb, while higher levels of c-Myb result in reduced Myb-induced trans-activation. By contrast, thisapparent negative autoregulation is not observed with a c-Myb mutant containing an impaired leucine zipper. Data presented here suggest that this negative autoregulation of trans-activation by wild-type c-Myb is a consequence of homodimer formation by c-Myb through its leucine zipper and of the inability of c-Myb dimers to bind DNA. These findingspoint to a novel mechanism of regulation of a transcription factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:21:41