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Titolo:
REPRODUCIBILITY OF THE ORAL GLUCOSE-TOLERANCE TEST IN PREGNANT-WOMEN
Autore:
CATALANO PM; AVALLONE DA; DRAGO NM; AMINI SB;
Indirizzi:
METROHLTH MED CTR,CASE WESTERN RESERVE UNIV,DEPT REPROD,3395 SCRANTONRD CLEVELAND OH 44109
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 4, volume: 169, anno: 1993,
pagine: 874 - 881
SICI:
0002-9378(1993)169:4<874:ROTOGT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN; NOREPINEPHRINE; EPINEPHRINE;
Keywords:
ORAL GLUCOSE TOLERANCE TEST; PREGNANCY; GESTATIONAL DIABETES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
P.M. Catalano et al., "REPRODUCIBILITY OF THE ORAL GLUCOSE-TOLERANCE TEST IN PREGNANT-WOMEN", American journal of obstetrics and gynecology, 169(4), 1993, pp. 874-881

Abstract

OBJECTIVE: The purpose of this study was to evaluate the reproducibility of the 3-hour oral glucose tolerance test during pregnancy and thepotential factors associated with nonreproducible results. STUDY DESIGN: Thirty-eight women with a 1-hour glucose level greater-than-or-equal-to 135 mg/dl had a 100 gm oral glucose tolerance test. During the test samples were obtained for glucose, insulin, cortisol, human placental lactogen, and norepinephrine levels, The oral glucose tolerance test was repeated 1 week later under similar metabolic conditions. RESULTS: The intraassay coefficient of variation in glucose from week 1 to week 2 was <2%. There were no significant differences in the paired fasting l-, 2-, or 3-hour glucose concentrations (p = 0.51 to 0.96) or the area under the glucose curve (p = 0.43) from week 1 to week 2, although the mean absolute difference in glucose values ranged from 4 (fasting) to 18 (3 hours) mg/dl. Oral glucose tolerance test results were classified as either normal or abnormal from week 1 to week 2: 16 normal/normal, 13 abnormal/abnormal, seven abnormal/normal, and two normal/abnormal. Norepinephrine (p = 0.03) and insulin (p = 0.05) were significantly greater in week 1 but not in week 2 in the abnormal/normal versus normal/normal and abnormal/abnormal groups. There were no significant differences in cortisol or human placental lactogen levels among groups at any time. CONCLUSIONS: The oral glucose tolerance test was not reproducible for diagnosis in 24% (nine of 38) of pregnant women. We speculate that maternal stress (increased norepinephrine) may have been a factor for the abnormal results in week 1 in the abnormal/normalgroup.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:15:57