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Titolo:
QUANTIFICATION OF THE CROSS-LINK PENTOSIDINE IN SERUM FROM NORMAL ANDUREMIC SUBJECTS
Autore:
TAKAHASHI M; KUSHIDA K; KAWANA K; ISHIHARA C; DENDA M; INOUE T; HORIUCHI K;
Indirizzi:
HAMAMATSU UNIV,SCH MED,DEPT ORTHOPED SURG,3600 HANDA HAMAMATSU SHIZUOKA 43131 JAPAN HAMAMATSU UNIV,SCH MED,DEPT CHEM HAMAMATSU SHIZUOKA 43131 JAPAN
Titolo Testata:
Clinical chemistry
fascicolo: 10, volume: 39, anno: 1993,
pagine: 2162 - 2165
SICI:
0009-9147(1993)39:10<2162:QOTCPI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Keywords:
CHROMATOGRAPHY, REVERSED-PHASE; HEMODIALYSIS; RENAL FUNCTION; AGE-RELATED EFFECTS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Takahashi et al., "QUANTIFICATION OF THE CROSS-LINK PENTOSIDINE IN SERUM FROM NORMAL ANDUREMIC SUBJECTS", Clinical chemistry, 39(10), 1993, pp. 2162-2165

Abstract

Pentosidine is a fluorescent cross-link compound that accumulates in human tissues from uremic and diabetic patients. Using SP-Sephadex C-25 pretreatment before reversed-phase HPLC, we developed a method for quantifying pentosidine in the acid hydrolysate of serum. We examined concentrations of pentosidine in serum from 98 patients with end-stage renal disease requiring hemodialysis and from 33 normal control subjects. The mean (+/- SD) concentration of pentosidine was significantly greater in serum from uremic patients than that from control subjects (1267 +/- 695 nmol/L vs 77 +/- 40 nmol/L, P = 0.0001). There was a significant correlation between serum pentosidine concentrations and age in control subjects (r = 0.453, P < 0.01), but not in uremic patients. Serum pentosidine significantly increased with the duration of hemodialysis treatment (r = 0.272, P < 0.05). The greater pentosidine concentrations in uremic patients may be caused by the increased synthesis ofpentosidine (perhaps because of the retention of pentosidine precursors), by the retention of pentosidine molecule itself in end-stage renal failure, or both.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:26:30