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Titolo:
SYNTHESIS, IN-VITRO BINDING PROFILE, AND AUTORADIOGRAPHIC ANALYSIS OF[H-3] CIS-3-[(2-METHOXYBENZYL)AMINO]-2-PHENYLPIPERIDINE, A HIGHLY POTENT AND SELECTIVE NONPEPTIDE SUBSTANCE-P RECEPTOR ANTAGONIST RADIOLIGAND
Autore:
ROSEN T; SEEGER TF; MCLEAN S; DESAI MC; GUARINO KJ; BRYCE D; PRATT K; HEYM J; CHALABI PM; WINDELS JH; ROTH RW;
Indirizzi:
PFIZER INC,CENT RES,DEPT MED CHEM GROTON CT 06340 PFIZER INC,CENT RES,DEPT NEUROSCI GROTON CT 06340 CHEMSYN SCI LABS LENEXA KS 66215
Titolo Testata:
Journal of medicinal chemistry
fascicolo: 21, volume: 36, anno: 1993,
pagine: 3197 - 3201
SICI:
0022-2623(1993)36:21<3197:SIBPAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NK1 RECEPTOR; BRAIN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Rosen et al., "SYNTHESIS, IN-VITRO BINDING PROFILE, AND AUTORADIOGRAPHIC ANALYSIS OF[H-3] CIS-3-[(2-METHOXYBENZYL)AMINO]-2-PHENYLPIPERIDINE, A HIGHLY POTENT AND SELECTIVE NONPEPTIDE SUBSTANCE-P RECEPTOR ANTAGONIST RADIOLIGAND", Journal of medicinal chemistry, 36(21), 1993, pp. 3197-3201

Abstract

The synthesis of a highly potent and selective NK1 receptor antagonist radioligand, ]cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine (6a)is described. The in vitro binding pharmacology and autoradiographic distribution of 6a in guinea pig brain following peripheral administration are also reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:11:23