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Titolo:
IMPACT OF RESPIRATORY VIRUS-INFECTION IN PATIENTS WITH CHRONIC CHEST DISEASE
Autore:
WISELKA MJ; KENT J; COOKSON JB; NICHOLSON KG;
Indirizzi:
LEICESTER ROYAL INFIRM,DEPT INFECT DIS LEICESTER LE1 5WW ENGLAND GLENFIELD GEN HOSP,DEPT RESP MED LEICESTER LE3 9QQ ENGLAND
Titolo Testata:
Epidemiology and infection
fascicolo: 2, volume: 111, anno: 1993,
pagine: 337 - 346
SICI:
0950-2688(1993)111:2<337:IORVIP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRANASAL ALPHA-2-INTERFERON; RHINOVIRUS INFECTIONS; SEASONAL PROPHYLAXIS; VIRAL-INFECTIONS; ASTHMA; EXACERBATIONS; PRECIPITANTS; CORONAVIRUS; BRONCHITIS; INTERFERON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Wiselka et al., "IMPACT OF RESPIRATORY VIRUS-INFECTION IN PATIENTS WITH CHRONIC CHEST DISEASE", Epidemiology and infection, 111(2), 1993, pp. 337-346

Abstract

This study investigated the morbidity associated with respiratory virus infections in patients with well-documented chest disease, and the risk of transmission between close contacts. Patients informed the study team if they were exposed to a family member or colleague with a cold. Patients and symptomatic index cases recorded respiratory symptomsduring the study period. Acute nasopharyngeal swabs and paired sera were obtained for viral diagnosis. Twenty-five (43%) of 58 recorded exposures resulted in a symptomatic illness and 16 (28%) patients developed lower respiratory tract symptoms. Sixteen (64%) of the 25 symptomatic patients contacted their general practitioner, 14 (56%) received antibiotics and 4 (16%) were hospitalized. Mean duration of illness was 10.6 days in symptomatic patients and 5.7 days in their corresponding index cases (P < 0.005). Mean symptom scores were 100.6 in symptomaticpatients and 62.2 in index cases (P < 0.01). Respiratory viruses wereidentified in 19 (33%) episodes. Rhinovirus, coronavirus and respiratory syncytial virus infections were all associated with lower respiratory tract exacerbations. Respiratory tract symptoms following exposureto a cold were comparatively severe in these patients with chronic chest disease. This group of patients might gain particular benefit fromthe introduction of effective vaccines or antiviral therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:37:15