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Titolo:
EFFECT OF POSTISCHEMIC REPERFUSION ON THE PANCREAS
Autore:
TAMURA K; MANABE T; KYOGOKU T; ANDOH K; OHSHIO G; TOBE T;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT SURG 1,54 KAWARA CHO,SHOGOIN,SAKYO KU KYOTO 606 JAPAN
Titolo Testata:
Hepato-gastroenterology
fascicolo: 5, volume: 40, anno: 1993,
pagine: 452 - 456
SICI:
0172-6390(1993)40:5<452:EOPROT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICALS; RAT-BRAIN; ISCHEMIA; PATHOGENESIS; GLUTATHIONE; RELEASE; MUSCLE; HEART;
Keywords:
ACUTE PANCREATITIS; POSTISCHEMIC REPERFUSION; FREE RADICALS; SUPEROXIDE DISMUTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
K. Tamura et al., "EFFECT OF POSTISCHEMIC REPERFUSION ON THE PANCREAS", Hepato-gastroenterology, 40(5), 1993, pp. 452-456

Abstract

In an examination of the effect of ischemia and reperfusion on the generation of active oxygen species during pancreatic cell damage, a short-term ischemia and reperfusion model was prepared by the occlusion and reperfusion of both the anterior mesenteric artery and the celiac artery in rats. Following 60 minutes of occlusion plus 7 hours of reperfusion of the anterior mesenteric artery and the celiac artery, the serum concentrations of amylase and lipase rose significantly to 7 and 6times the respective control values. After 30 minutes of occlusion plus 7 hours of reperfusion, or after 7 hours of occlusion without. reperfusion, amylase and lipase levels were not changed significantly. Thecontinuous intravenous infusion of superoxide dismutase (3600 U/kg/hour) in rats receiving 60 minutes of occlusion plus 7 hours of reperfusion suppressed the rise in serum amylase and lipase values to 25 percent of the values in the non-injected group. These results suggest thatthe active oxygen species which are generated by the short-term ischemia and reperfusion method injure the endothelium and cause hyperamylasemia and hyperlipasemia. Inhibition of the rise in serum amylase and lipase concentrations by pretreatment with a scavenger of active oxygen, superoxide dismutase, suggests that the active oxygen species are involved in the pathogenesis of acute pancreatitis.

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Documento generato il 13/07/20 alle ore 10:31:25