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Titolo:
NULL MUTATION OF THE PROLACTIN RECEPTOR GENE PRODUCES MULTIPLE REPRODUCTIVE DEFECTS IN THE MOUSE
Autore:
ORMANDY CJ; CAMUS A; BARRA J; DAMOTTE JD; LUCAS B; BUTEAU H; EDERY M; BROUSSE N; BABINET C; BINART N; KELLY PA;
Indirizzi:
FAC MED NECKER ENFANTS MALAD,INSERM U 344 PARIS FRANCE FAC MED NECKER ENFANTS MALAD,INSERM U 344 PARIS FRANCE INST PASTEUR,URA CNRS,UNITE BIOL DEV,IP 1960 PARIS FRANCE HOP NECKER ENFANTS MALAD,SERV ANATOMOPATHOL PARIS FRANCE
Titolo Testata:
Genes & development
fascicolo: 2, volume: 11, anno: 1997,
pagine: 167 - 178
SICI:
0890-9369(1997)11:2<167:NMOTPR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY-PREGNANCY FACTOR; MESSENGER-RIBONUCLEIC-ACID; BREAST-CANCER-CELLS; PLATELET-ACTIVATING FACTOR; GROWTH-HORMONE; FOLLICULAR-FLUID; INVITRO FERTILIZATION; BINDING DOMAIN; HUMAN OOCYTES; FETAL-RAT;
Keywords:
PROLACTIN RECEPTOR GENE; MOUSE REPRODUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Ormandy et al., "NULL MUTATION OF THE PROLACTIN RECEPTOR GENE PRODUCES MULTIPLE REPRODUCTIVE DEFECTS IN THE MOUSE", Genes & development, 11(2), 1997, pp. 167-178

Abstract

Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly reduced mammary gland development after their first, but not subsequent, pregnancies. Homozygous females were sterile owing to a complete failure of embryonic implantation. Moreover, they presentedmultiple reproductive abnormalities, including irregular cycles, reduced fertilization rates, defective preimplantation embryonic development, and lack of pseudopregnancy. Half of the homozygous males were infertile or showed reduced fertility. This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolactin receptor and its ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:39:44