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Titolo:
INHIBITION OF REV ACTIVITY AND HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE ANALOGS DIRECTED AGAINST THE REV-RESPONSIVE ELEMENT
Autore:
LI G; LISZIEWICZ J; SUN D; ZON G; DAEFLER S; WONGSTAAL F; GALLO RC; KLOTMAN ME;
Indirizzi:
NCI,TUMOR CELL BIOL LAB BETHESDA MD 20892 NCI,TUMOR CELL BIOL LAB BETHESDA MD 20892 LYNX THERAPEUT INC FOSTER CITY CA 94404 NYU MED CTR,DEPT MED NEW YORK NY 10016 UNIV CALIF SAN DIEGO,DEPT MED LA JOLLA CA 92093
Titolo Testata:
Journal of virology
fascicolo: 11, volume: 67, anno: 1993,
pagine: 6882 - 6888
SICI:
0022-538X(1993)67:11<6882:IORAAH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAL MESSENGER-RNA; ACETYLTRANSFERASE GENE-EXPRESSION; CHRONICALLY INFECTED-CELLS; RETROVIRUSES HTLV-III; HIV-1 REV; TARGET SEQUENCE; TRANS-ACTIVATOR; SECONDARY STRUCTURE; VIRION EXPRESSION; REGULATORY GENES;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
G. Li et al., "INHIBITION OF REV ACTIVITY AND HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION BY ANTISENSE OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE ANALOGS DIRECTED AGAINST THE REV-RESPONSIVE ELEMENT", Journal of virology, 67(11), 1993, pp. 6882-6888

Abstract

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:01:53